DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRTPQLT
Uniprot ID:
Q5VU36
Source protein:
Spermatogenesis-associated protein 31A5
Source gene:
SPATA31A5
Class:
DEG_SCF_FBW7_1
Location:
1128:1134
E3 ligase:
FBXW7
DEGRON score:
0.7927
ASA_SCORE:
101.2286
COIL:
0.9253
CONS_SCORE:
0.3473
DSS_SCORE:
0.687
HELIX:
0.0344
FCONS_SCORE:
1.0219
RIG_SCORE:
0.6565
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31A5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRTPQLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_SCF_FBW7_1
1128:1134
LRTPQLT
FBXW7
0.9898
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
DEG_SCF_FBW7_1
1128:1134
LRTPQLT
FBXW7
0.7927
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_SCF_FBW7_1
1128:1134
LRTPQLT
FBXW7
0.7927
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
DEG_SCF_FBW7_1
1124:1130
LRTPQLT
FBXW7
0.9898
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_SCF_FBW7_1
1128:1134
LRTPQLT
FBXW7
0.749
More...