DegronMD

Uniprot ID: Q5TZJ5

Source protein: Spermatogenesis-associated protein 31A1

Source gene: SPATA31A1

Class: DEG_SCF_FBW7_1

Location: 1128:1134

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 97.8714

COIL: 0.9346

CONS_SCORE: 0.3583

DSS_SCORE: 0.6845

HELIX: 0.0287

FCONS_SCORE: 1.2943

RIG_SCORE: 0.6565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1144K	TCGA-14-1823	GBM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.Q1144K	TCGA-A5-A0G1	UCEC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.Q1144K	DO12070	GBM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.Q1144K	DO42472	UCEC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.R1124M	TCGA-CD-A4MG	STAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.R1124M	DO48009	STAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.K1138T	TCGA-E6-A1LX	UCEC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.3333
p.K1138T	DO41020	UCEC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.3333
p.S1124T	SIDM01197	Colorectal Carcinoma	GDSC	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.R1138M	SIDM00889	Cervical Carcinoma	GDSC	LRTPQLT	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.9898	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SCF_FBW7_1	1124:1130	LRTPQLT	FBXW7	0.9898	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons