DegronMD

Uniprot ID: Q5VVP1

Source protein: Spermatogenesis-associated protein 31A6

Source gene: SPATA31A6

Class: DEG_SPOP_SBC_1

Location: 1195:1199

E3 ligase: SPOP

DEGRON score: 0.982

ASA_SCORE: 78.94

COIL: 0.7484

CONS_SCORE: 0.2805

DSS_SCORE: 0.3298

HELIX: 0.1222

FCONS_SCORE: 0.6364

RIG_SCORE: 0.7625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1207K	TCGA-17-Z061	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1111
p.C1194Y	TCGA-50-5933	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.3056
p.C1194Y	DO24800	LUAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.M1206I	TCGA-BR-7723	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1389
p.M1206I	DO38875	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1389
p.T1207M	TCGA-CH-5769	PRAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1111
p.T1207M	DO36245	PRAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1111
p.K1190E	SIDM00625	Other Sarcomas	GDSC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.K1190E	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.E1201K	SIDM01090	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.K1187Q	SIDM00193	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.Q1203R	SIDM01608	Endometrial Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons