DegronMD - Q8IZJ1(UNC5B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S492F	TCGA-A5-A2K5	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.S492F	DO41379	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.T490M	TCGA-AA-3947	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.T490M	TCGA-CM-4750	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.T490M	DO8192	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.T490M	DO9298	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.P478S	TCGA-AD-6889	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.P478S	DO8463	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.S479N	TCGA-AP-A059	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1944
p.S479N	DO41361	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1944
p.V482F	DO229009	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.V482I	DO222521	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.D498H	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.0556
p.D498H	ACH-000840	Lung Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.0556
p.D498H	HCC-366	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.0556
p.K483N	ACH-002287	Colon/Colorectal Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.3056
p.K483N	NCI-H630	large intestine	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.3056
p.V494I	COLO-792	skin	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.A489V	KALS-1	central nervous system	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.3056
p.L491M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.25
p.D487H	HCC-366	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7688

Kaplan plot for UNC5B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC5B

UniProt ID: Q8IZJ1

Entrez ID: 219699

Protein name: Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC5B in