DegronMD

Uniprot ID: Q8IZJ1

Source protein: Netrin receptor UNC5B

Source gene: UNC5B

Class: DEG_SPOP_SBC_1

Location: 484:488

E3 ligase: SPOP

DEGRON score: 0.9604

ASA_SCORE: 64.72

COIL: 0.7412

CONS_SCORE: 0.2883

DSS_SCORE: 0.4273

HELIX: 0.0418

FCONS_SCORE: 0.833

RIG_SCORE: 0.6973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S492F	TCGA-A5-A2K5	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2222
p.S492F	DO41379	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.T490M	TCGA-AA-3947	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2778
p.T490M	TCGA-CM-4750	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2778
p.T490M	DO8192	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.T490M	DO9298	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.P478S	TCGA-AD-6889	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1667
p.P478S	DO8463	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1667
p.S479N	TCGA-AP-A059	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1944
p.S479N	DO41361	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1944
p.V482F	DO229009	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.V482I	DO222521	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.D498H	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.D498H	ACH-000840	Lung Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	0.0556
p.D498H	HCC-366	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.K483N	ACH-002287	Colon/Colorectal Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	0.3056
p.K483N	NCI-H630	large_intestine	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.V494I	COLO-792	skin	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.1667
p.A489V	KALS-1	central_nervous_system	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.L491M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.25
p.D487H	HCC-366	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons