DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: DEG_SPOP_SBC_1

Location: 62:66

E3 ligase: SPOP

DEGRON score: 0.9965

ASA_SCORE: 69.5

COIL: 0.7842

CONS_SCORE: 0.3446

DSS_SCORE: 0.5206

HELIX: 0.0336

FCONS_SCORE: 1.0059

RIG_SCORE: 0.6754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P76Q	TCGA-53-7626	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.0556
p.P76Q	DO23774	LUAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.S64W	TCGA-DK-AA71	BLCA	TCGA	VYSSS	DEG_SPOP_SBC_1	0.7874
p.S64W	DO219010	BLCA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.7874
p.L52F	TCGA-HU-8608	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.0556
p.L52F	DO47841	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.A60D	DO52758	CMDI	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.D70N	DO50725	ORCA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.P76L	ACH-002687	Metastasis	CCLE	VYSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons