DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VYSSS
Uniprot ID:
Q8IWB4
Source protein:
Spermatogenesis-associated protein 31A7
Source gene:
SPATA31A7
Class:
DEG_SPOP_SBC_1
Location:
1199:1203
E3 ligase:
SPOP
DEGRON score:
0.9981
ASA_SCORE:
78.88
COIL:
0.714
CONS_SCORE:
0.2969
DSS_SCORE:
0.4221
HELIX:
0.1004
FCONS_SCORE:
0.5947
RIG_SCORE:
0.7222
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31A7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VYSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60307
Microtubule-associated serine/threonine-protein kinase 3
DEG_SPOP_SBC_1
707:711
VYSSS
SPOP
0.9777
More...
O75494
Serine/arginine-rich splicing factor 10
DEG_SPOP_SBC_1
104:108
VYSSS
SPOP
0.9991
More...
O75694
Nuclear pore complex protein Nup155
DEG_SPOP_SBC_1
602:606
VYSSS
SPOP
0.7963
More...
Q8IZJ1
Netrin receptor UNC5B
DEG_SPOP_SBC_1
484:488
VYSSS
SPOP
0.9604
More...
Q92753
Nuclear receptor ROR-beta
DEG_SPOP_SBC_1
132:136
VYSSS
SPOP
0.5622
More...
Q9H9J4
Ubiquitin carboxyl-terminal hydrolase 42
DEG_SPOP_SBC_1
62:66
VYSSS
SPOP
0.9965
More...
Q9UID3
Vacuolar protein sorting-associated protein 51 homolog
DEG_SPOP_SBC_1
650:654
VYSSS
SPOP
0.9994
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1303:1307
VYSSS
SPOP
0.6435
More...
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_SPOP_SBC_1
1199:1203
VYSSS
SPOP
0.6282
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
DEG_SPOP_SBC_1
1199:1203
VYSSS
SPOP
0.9981
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_SPOP_SBC_1
1199:1203
VYSSS
SPOP
0.9754
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
DEG_SPOP_SBC_1
1195:1199
VYSSS
SPOP
0.982
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_SPOP_SBC_1
1199:1203
VYSSS
SPOP
0.6896
More...