DegronMD - O75694(NUP155)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A17V	TCGA-BT-A20J	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.A17V	DO457	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.L598F	TCGA-G7-6793	KIRP	TCGA	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.2222
p.L598F	DO20835	KIRP	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.2222
p.A8T	TCGA-GV-A40G	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.A8T	DO584	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.G611S	TCGA-OR-A5JD	ACC	TCGA	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1944
p.S13C	TCGA-VS-A954	CESC	TCGA	PASTS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.8652
p.S13C	DO51637	CESC	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.8652
p.S4F	DO218227	BTCA	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation blocking phosphorylation signal	0.5833
p.P613L	DO50452	ESAD	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1389
p.P17R	DO233773	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.P615T	DO229029	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.0833
p.A18V	DO50970	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.A17S	DO231768	LINC	ICGC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.S592N	DO220852	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.0556
p.G606C	DO37447	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation altering degron motif	0.76
p.G606C	DO51236	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation altering degron motif	0.76
p.Y614C	SIDM00773	Non-Cancerous	GDSC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1111
p.Y614C	SIDM00774	Breast Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1111
p.Y614C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation rewiring degron network	0.1111
p.T14A	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7139
p.T14A	ACH-000338	Lymphoma	CCLE	PASTS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7139
p.T14A	SR	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7139
p.Y603C	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation altering degron motif	0.5976
p.Y603C	ACH-000666	Lung Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation altering degron motif	0.5976
p.Y603C	NCI-H1355	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	602:606	Mutation altering degron motif	0.5976
p.A9V	SIDM00410	Other Blood Cancers	GDSC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.A9V	ACH-002317	Leukemia	CCLE	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.A9V	YT	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.2778
p.A22V	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.A22V	ACH-000131	Non-Cancerous	CCLE	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.V16A	SHP-77	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.3056

Kaplan plot for NUP155 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP155

UniProt ID: O75694

Entrez ID: 9631

Protein name: Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUP155 in