DegronMD

Uniprot ID: O75694

Source protein: Nuclear pore complex protein Nup155

Source gene: NUP155

Class: DEG_SPOP_SBC_1

Location: 602:606

E3 ligase: SPOP

DEGRON score: 0.7963

ASA_SCORE: 75.12

COIL: 0.817

CONS_SCORE: 0.2295

DSS_SCORE: 0.4461

HELIX: 0.0404

FCONS_SCORE: 0.9642

RIG_SCORE: 0.6138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L598F	TCGA-G7-6793	KIRP	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2222
p.L598F	DO20835	KIRP	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.G611S	TCGA-OR-A5JD	ACC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1944
p.P613L	DO50452	ESAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1389
p.P615T	DO229029	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0833
p.S592N	DO220852	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.G606C	DO37447	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	0.76
p.G606C	DO51236	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	0.76
p.Y614C	SIDM00773	Non-Cancerous	GDSC	VYSSS	DEG_SPOP_SBC_1	0.1111
p.Y614C	SIDM00774	Breast Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.1111
p.Y614C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VYSSS	DEG_SPOP_SBC_1	0.1111
p.Y603C	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.5976
p.Y603C	ACH-000666	Lung Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	0.5976
p.Y603C	NCI-H1355	lung	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons