DegronMD - Q92753(RORB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D171E	TCGA-14-0736	GBM	TCGA	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.6758
p.D171E	DO10875	GBM	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.6758
p.N134S	TCGA-23-1022	OV	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7069
p.N134S	DO31070	OV	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7069
p.V146I	TCGA-5M-AATE	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.V146I	TCGA-BR-6453	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.V146I	DO223704	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.V146I	DO38543	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.S160F	TCGA-CA-6717	COAD	TCGA	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.0556
p.S160F	DO8264	COAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.0556
p.N132D	TCGA-CG-5721	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6932
p.N132D	DO38192	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6932
p.L133M	TCGA-DA-A1IB	SKCM	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.711
p.L133M	TCGA-FS-A1Z0	SKCM	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.711
p.L133M	DO37431	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.711
p.L133M	DO38033	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.711
p.P165S	TCGA-EB-A41A	SKCM	TCGA	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1944
p.P165S	DO234401	ESAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1944
p.P165S	DO37429	SKCM	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1944
p.S164F	TCGA-EM-A2CM	THCA	TCGA	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1667
p.S164F	DO39228	THCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1667
p.E136K	TCGA-IN-A6RL	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7022
p.E136K	DO35242	PACA	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7022
p.E136K	DO51738	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7022
p.G174A	DO1098	BRCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.754
p.S138R	DO222492	COCA	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2778
p.T140I	DO228390	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.Q167H	DO229038	LICA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.25
p.N134D	DO44806	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6932
p.G144R	SIDM01314	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.M172V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.7208
p.M172V	ACH-000924	Lung Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.7208
p.M172V	NCI-H2172	lung	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation altering degron motif	0.7208
p.G165S	U-118-MG	central nervous system	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1944
p.M183V	NCI-H2172	lung	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	170:175	Mutation rewiring degron network	0.1111

Kaplan plot for RORB in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RORB

UniProt ID: Q92753

Entrez ID:

Protein name: Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RORB in