DegronMD

Uniprot ID: Q92753

Source protein: Nuclear receptor ROR-beta

Source gene: RORB

Class: DEG_SPOP_SBC_1

Location: 132:136

E3 ligase: SPOP

DEGRON score: 0.5622

ASA_SCORE: 51.92

COIL: 0.4444

CONS_SCORE: 0.5538

DSS_SCORE: 0.3863

HELIX: 0.3356

FCONS_SCORE: 1.1743

RIG_SCORE: 0.7345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N134S	TCGA-23-1022	OV	TCGA	VYSSS	DEG_SPOP_SBC_1	0.7069
p.N134S	DO31070	OV	ICGC	VYSSS	DEG_SPOP_SBC_1	0.7069
p.V146I	TCGA-5M-AATE	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.0556
p.V146I	TCGA-BR-6453	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.0556
p.V146I	DO223704	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.V146I	DO38543	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.N132D	TCGA-CG-5721	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.6932
p.N132D	DO38192	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.6932
p.L133M	TCGA-DA-A1IB	SKCM	TCGA	VYSSS	DEG_SPOP_SBC_1	0.711
p.L133M	TCGA-FS-A1Z0	SKCM	TCGA	VYSSS	DEG_SPOP_SBC_1	0.711
p.L133M	DO37431	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	0.711
p.L133M	DO38033	SKCM	ICGC	VYSSS	DEG_SPOP_SBC_1	0.711
p.E136K	TCGA-IN-A6RL	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	0.7022
p.E136K	DO35242	PACA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.7022
p.E136K	DO51738	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	0.7022
p.S138R	DO222492	COCA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2778
p.T140I	DO228390	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.N134D	DO44806	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.6932
p.G144R	SIDM01314	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons