DegronMD - Q9H9J4(USP42)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1299Q	TCGA-2H-A9GI	ESCA	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299Q	TCGA-D1-A103	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299Q	DO42312	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.P76Q	TCGA-53-7626	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.P76Q	DO23774	LUAD	ICGC	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.T571S	TCGA-55-7907	LUAD	TCGA	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.2222
p.T571S	DO25396	LUAD	ICGC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.2222
p.E617K	TCGA-66-2795	LUSC	TCGA	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1667
p.E617K	DO26710	LUSC	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1667
p.E617K	SIDM00014	Colorectal Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1667
p.E617K	LIM1215	large intestine	COSMIC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1667
p.G1289R	TCGA-98-A53I	LUSC	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.6457
p.G1289R	TCGA-AG-A002	READ	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.6457
p.G1289R	TCGA-AX-A06F	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.6457
p.G1289R	DO219182	LUSC	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.6457
p.G1289R	DO41752	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.6457
p.D1130G	TCGA-AD-5900	COAD	TCGA	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation altering degron motif	0.7198
p.D1130G	DO8514	COAD	ICGC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation altering degron motif	0.7198
p.P1283L	TCGA-AJ-A3EK	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1944
p.P1283L	DO41584	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1944
p.R1136I	TCGA-AP-A059	UCEC	TCGA	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.R1136I	DO41361	UCEC	ICGC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.G629D	TCGA-AX-A1CE	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.2778
p.G629D	DO42280	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.2778
p.R1131C	TCGA-AY-6197	COAD	TCGA	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.3056
p.R1131C	DO9956	COAD	ICGC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.3056
p.R1292H	TCGA-BR-7851	STAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.7133
p.R1292H	TCGA-D7-A6EY	STAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.7133
p.R1292H	DO50118	STAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.7133
p.R1292H	DO38711	STAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.7133
p.R1299W	TCGA-CM-6674	COAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299W	DO10092	COAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299W	SIDM00234	Other Solid Cancers	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299W	SIDM00281	Other Solid Cancers	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299W	SIDM00556	Neuroblastoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1299W	SIDM00511	Small Cell Lung Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.S543G	TCGA-CN-A63W	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.S543G	DO49031	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.S64W	TCGA-DK-AA71	BLCA	TCGA	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7874
p.S64W	DO219010	BLCA	ICGC	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7874
p.G1281C	TCGA-EB-A1NK	SKCM	TCGA	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1389
p.G1281C	DO37695	SKCM	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1389
p.S543I	TCGA-EY-A215	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.S543I	DO42665	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.I628N	TCGA-G4-6588	COAD	TCGA	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.3056
p.I628N	DO10140	COAD	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.3056
p.V553I	TCGA-HU-8602	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7076
p.V553I	DO47829	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7076
p.V553I	SIDM01619	Endometrial Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7076
p.V553I	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7076
p.L52F	TCGA-HU-8608	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.L52F	DO47841	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.A60D	DO52758	CMDI	ICGC	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.S483N	DO228079	EOPC	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation blocking phosphorylation signal	0.6944
p.M572T	DO234383	ESAD	ICGC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.1944
p.S480T	DO233058	GACA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.6005
p.I631T	DO233154	GACA	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.2222
p.V574F	DO228359	LICA	ICGC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.1389
p.R1303S	DO228976	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.0556
p.G486W	DO229019	LICA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.1667
p.Q564H	DO229028	LICA	ICGC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation altering degron motif	0.647
p.V632L	DO229025	LICA	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1944
p.R1299L	DO229009	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1667
p.R1292C	DO50757	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.719
p.R1292C	DO229114	PRAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.719
p.R1292C	ACH-001518	Endometrial/Uterine Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation altering degron motif	0.719
p.T476S	DO50819	LIRI	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.7116
p.A1119T	DO228308	MALY	ICGC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.N485S	DO222572	MELA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.1944
p.D70N	DO50725	ORCA	ICGC	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2222
p.G621V	DO232224	PBCA	ICGC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.2778
p.T476M	DO41199	UCEC	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.7423
p.A1121T	SIDM02049	Pancreatic Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.2222
p.G1287A	SIDM00393	Gastric Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.3056
p.G1287A	ACH-001653	Gastric Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.3056
p.G1287A	SK-GT-2	stomach	COSMIC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.3056
p.V1140L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.0556
p.V1140L	ACH-000843	Lung Cancer	CCLE	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.0556
p.V1140L	HARA	lung	COSMIC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.0556
p.R1136K	SIDM00350	Head and Neck Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.R1136K	ACH-001641	Head and Neck Cancer	CCLE	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.R1136K	SAT	upper aerodigestive tract	COSMIC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1667
p.G1281D	SIDM00238	Ovarian Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1389
p.G1281D	ACH-000947	Ovarian Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1389
p.G1281D	OVK-18	ovary	COSMIC	VGPFRE	LIG_APCC_ABBA_1	1288:1293	Mutation rewiring degron network	0.1389
p.A1124T	SIDM00014	Colorectal Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.3056
p.A1124T	LIM1215	large intestine	COSMIC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.3056
p.L546S	SIDM00792	Small Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.L546S	NCI-H1688	lung	COSMIC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.T1137N	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1389
p.T1137N	ACH-000920	Leukemia	CCLE	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1389
p.T1137N	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.1389
p.H635L	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1111
p.H635L	ACH-000747	Lung Cancer	CCLE	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1111
p.H635L	NCI-H1703	lung	COSMIC	GKENG	DEG_APCC_KENBOX_2	623:627	Mutation rewiring degron network	0.1111
p.I558V	SIDM01000	Melanoma	GDSC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.I558V	SIDM01000	Melanoma	GDSC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.1944
p.I558V	ACH-000304	Skin Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.I558V	ACH-000304	Skin Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.1944
p.I558V	WM-115	skin	COSMIC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.I558V	WM-115	skin	COSMIC	VQSTS	DEG_SPOP_SBC_1	563:567	Mutation rewiring degron network	0.1944
p.S556C	SIDM00863	Burkitt's Lymphoma	GDSC	VPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7541
p.G471V	ACH-002042	Thyroid Cancer	CCLE	LKDTPSSS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.2778
p.P76L	ACH-002687	Metastasis	CCLE	VYSSS	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.V1140I	CW-2	large intestine	COSMIC	LAPHPD	LIG_APCC_ABBA_1	1125:1130	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP42

UniProt ID: Q9H9J4

Entrez ID: 84132

Protein name: Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP42 in