DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VQSTS
Uniprot ID:
Q9H9J4
Source protein:
Ubiquitin carboxyl-terminal hydrolase 42
Source gene:
USP42
Class:
DEG_SPOP_SBC_1
Location:
563:567
E3 ligase:
SPOP
DEGRON score:
0.8424
ASA_SCORE:
102.28
COIL:
0.9552
CONS_SCORE:
0.3006
DSS_SCORE:
0.5559
HELIX:
0.0366
FCONS_SCORE:
1.0442
RIG_SCORE:
0.6547
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q564H
DO229028
LICA
ICGC
VQSTS
DEG_SPOP_SBC_1
0.647
p.T571S
TCGA-55-7907
LUAD
TCGA
VQSTS
DEG_SPOP_SBC_1
0.2222
p.T571S
DO25396
LUAD
ICGC
VQSTS
DEG_SPOP_SBC_1
0.2222
p.M572T
DO234383
ESAD
ICGC
VQSTS
DEG_SPOP_SBC_1
0.1944
p.I558V
SIDM01000
Melanoma
GDSC
VQSTS
DEG_SPOP_SBC_1
0.1944
p.I558V
ACH-000304
Skin Cancer
CCLE
VQSTS
DEG_SPOP_SBC_1
0.1944
p.I558V
WM-115
skin
COSMIC
VQSTS
DEG_SPOP_SBC_1
0.1944
p.V574F
DO228359
LICA
ICGC
VQSTS
DEG_SPOP_SBC_1
0.1389
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Drug responses associated with USP42 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VQSTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6XE24
RNA-binding motif, single-stranded-interacting protein 3
DEG_SPOP_SBC_1
297:301
VQSTS
SPOP
0.5818
More...
Q9H9J4
Ubiquitin carboxyl-terminal hydrolase 42
DEG_SPOP_SBC_1
563:567
VQSTS
SPOP
0.8424
More...
Showing 1 to 2 of 2 entries
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