DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: DEG_SPOP_SBC_1

Location: 563:567

E3 ligase: SPOP

DEGRON score: 0.8424

ASA_SCORE: 102.28

COIL: 0.9552

CONS_SCORE: 0.3006

DSS_SCORE: 0.5559

HELIX: 0.0366

FCONS_SCORE: 1.0442

RIG_SCORE: 0.6547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T571S	TCGA-55-7907	LUAD	TCGA	VQSTS	DEG_SPOP_SBC_1	0.2222
p.T571S	DO25396	LUAD	ICGC	VQSTS	DEG_SPOP_SBC_1	0.2222
p.M572T	DO234383	ESAD	ICGC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.V574F	DO228359	LICA	ICGC	VQSTS	DEG_SPOP_SBC_1	0.1389
p.Q564H	DO229028	LICA	ICGC	VQSTS	DEG_SPOP_SBC_1	0.647
p.I558V	SIDM01000	Melanoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.I558V	ACH-000304	Skin Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	0.1944
p.I558V	WM-115	skin	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XE24	RNA-binding motif, single-stranded-interacting protein 3	DEG_SPOP_SBC_1	297:301	VQSTS	SPOP	0.5818	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	563:567	VQSTS	SPOP	0.8424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons