DegronMD

Uniprot ID: Q6XE24

Source protein: RNA-binding motif, single-stranded-interacting protein 3

Source gene: RBMS3

Class: DEG_SPOP_SBC_1

Location: 297:301

E3 ligase: SPOP

DEGRON score: 0.5818

ASA_SCORE: 38.72

COIL: 0.8036

CONS_SCORE: 0.4319

DSS_SCORE: 0.312

HELIX: 0.1144

FCONS_SCORE: 0.982

RIG_SCORE: 0.7215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P304H	TCGA-A5-A0G2	UCEC	TCGA	VQSTS	DEG_SPOP_SBC_1	0.25
p.P291L	TCGA-B5-A1MX	UCEC	TCGA	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P291T	TCGA-EE-A3AC	SKCM	TCGA	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P307S	TCGA-PK-A5HB	ACC	TCGA	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P307S	SIDM00660	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P307S	ACH-000985	Colon/Colorectal Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P307S	LS-411N	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1667
p.Q296H	DO222309	DLBC	ICGC	VQSTS	DEG_SPOP_SBC_1	0.3056
p.P305L	DO234179	ESAD	ICGC	VQSTS	DEG_SPOP_SBC_1	0.2222
p.P305L	HT-115	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.2222
p.M309I	DO232761	PBCA	ICGC	VQSTS	DEG_SPOP_SBC_1	0.1111
p.P290T	DO37631	SKCM	ICGC	VQSTS	DEG_SPOP_SBC_1	0.1389
p.P290L	DO41999	UCEC	ICGC	VQSTS	DEG_SPOP_SBC_1	0.1389
p.P303H	DO41235	UCEC	ICGC	VQSTS	DEG_SPOP_SBC_1	0.2778
p.P307T	SIDM01136	Pancreatic Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.1667
p.P307T	PANC-08-13	pancreas	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1667
p.A288T	SIDM00983	Bladder Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.0833
p.T300I	SIDM00217	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.7078
p.T300I	ACH-000999	Colon/Colorectal Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	0.7078
p.T300I	SNU-1040	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.7078
p.P306L	SIDM00534	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.P306L	HT-115	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.P306S	LS-411N	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.T299I	SNU-1040	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.7078
p.P306T	PANC-08-13	pancreas	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1944
p.M290I	COLO-741	large_intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XE24	RNA-binding motif, single-stranded-interacting protein 3	DEG_SPOP_SBC_1	297:301	VQSTS	SPOP	0.5818	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	563:567	VQSTS	SPOP	0.8424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQSTS

Degron related mutations and impact score

Drug responses associated with RBMS3 mutations

All proteins holding degron of VQSTS