DegronMD - Q6XE24(RBMS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y64N	TCGA-2Y-A9H8	LIHC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1111
p.G55W	TCGA-5M-AAT6	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7825
p.S54C	TCGA-78-7220	LUAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7541
p.P304H	TCGA-A5-A0G2	UCEC	TCGA	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.N47S	TCGA-AA-3966	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.2222
p.P291L	TCGA-B5-A1MX	UCEC	TCGA	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.S46R	TCGA-BP-5201	KIRC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.S46R	DO17206	KIRC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.I65S	TCGA-D5-6926	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.0833
p.T61A	TCGA-EE-A29L	SKCM	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.T61A	DO222599	MELA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.T61A	DO37835	SKCM	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.P291T	TCGA-EE-A3AC	SKCM	TCGA	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.E56A	TCGA-EY-A1GI	UCEC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7701
p.P307S	TCGA-PK-A5HB	ACC	TCGA	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.P307S	SIDM00660	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.P307S	ACH-000985	Colon/Colorectal Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.P307S	LS-411N	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.N46S	DO10068	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1944
p.G54W	DO223703	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7825
p.I64S	DO8530	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1111
p.Q296H	DO222309	DLBC	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.P305L	DO234179	ESAD	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2222
p.P305L	HT-115	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2222
p.G55R	DO233085	GACA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7568
p.T41A	DO50940	LICA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.0556
p.Y63N	DO219535	LIHC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1389
p.S53C	DO24409	LUAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7541
p.M309I	DO232761	PBCA	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P290T	DO37631	SKCM	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.P290L	DO41999	UCEC	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.P303H	DO41235	UCEC	ICGC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778
p.E55A	DO41211	UCEC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation altering degron motif	0.7701
p.P307T	SIDM01136	Pancreatic Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.P307T	PANC-08-13	pancreas	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.A288T	SIDM00983	Bladder Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0833
p.T300I	SIDM00217	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7078
p.T300I	ACH-000999	Colon/Colorectal Cancer	CCLE	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7078
p.T300I	SNU-1040	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7078
p.P306L	SIDM00534	Colorectal Carcinoma	GDSC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.P306L	HT-115	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.Y64H	SIDM00839	Colorectal Carcinoma	GDSC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1111
p.Y64H	ACH-000950	Colon/Colorectal Cancer	CCLE	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1111
p.Y64H	LoVo	large intestine	COSMIC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1111
p.Y63H	LoVo	large intestine	COSMIC	NNSSGE	DEG_Kelch_Keap1_1	51:56	Mutation rewiring degron network	0.1389
p.P306S	LS-411N	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.T299I	SNU-1040	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7078
p.P306T	PANC-08-13	pancreas	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.M290I	COLO-741	large intestine	COSMIC	VQSTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMS3

UniProt ID: Q6XE24

Entrez ID: 27303

Protein name: RNA-binding motif, single-stranded-interacting protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBMS3 in