DegronMD

Uniprot ID: Q6XE24

Source protein: RNA-binding motif, single-stranded-interacting protein 3

Source gene: RBMS3

Class: DEG_Kelch_Keap1_1

Location: 51:56

E3 ligase: KEAP1

DEGRON score: 0.9633

ASA_SCORE: 102.55

COIL: 0.9287

CONS_SCORE: 0.5101

DSS_SCORE: 0.6688

HELIX: 0.054

FCONS_SCORE: 0.8646

RIG_SCORE: 0.5158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y64N	TCGA-2Y-A9H8	LIHC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.1111
p.G55W	TCGA-5M-AAT6	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.7825
p.S54C	TCGA-78-7220	LUAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.7541
p.N47S	TCGA-AA-3966	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.2222
p.S46R	TCGA-BP-5201	KIRC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.S46R	DO17206	KIRC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.I65S	TCGA-D5-6926	COAD	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.0833
p.T61A	TCGA-EE-A29L	SKCM	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.T61A	DO222599	MELA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.T61A	DO37835	SKCM	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.E56A	TCGA-EY-A1GI	UCEC	TCGA	NNSSGE	DEG_Kelch_Keap1_1	0.7701
p.N46S	DO10068	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1944
p.G54W	DO223703	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.7825
p.I64S	DO8530	COAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1111
p.G55R	DO233085	GACA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.7568
p.T41A	DO50940	LICA	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.0556
p.Y63N	DO219535	LIHC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.1389
p.S53C	DO24409	LUAD	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.7541
p.E55A	DO41211	UCEC	ICGC	NNSSGE	DEG_Kelch_Keap1_1	0.7701
p.Y64H	SIDM00839	Colorectal Carcinoma	GDSC	NNSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y64H	ACH-000950	Colon/Colorectal Cancer	CCLE	NNSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y64H	LoVo	large_intestine	COSMIC	NNSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y63H	LoVo	large_intestine	COSMIC	NNSSGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XE24	RNA-binding motif, single-stranded-interacting protein 3	DEG_Kelch_Keap1_1	51:56	NNSSGE	KEAP1	0.9633	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons