DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: LIG_APCC_ABBA_1

Location: 1288:1293

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.562

ASA_SCORE: 72.3667

COIL: 0.6405

CONS_SCORE: 0.2132

DSS_SCORE: 0.5716

HELIX: 0.2693

FCONS_SCORE: 1.0012

RIG_SCORE: 0.683

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1299Q	TCGA-2H-A9GI	ESCA	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299Q	TCGA-D1-A103	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299Q	DO42312	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.G1289R	TCGA-98-A53I	LUSC	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.6457
p.G1289R	TCGA-AG-A002	READ	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.6457
p.G1289R	TCGA-AX-A06F	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.6457
p.G1289R	DO219182	LUSC	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.6457
p.G1289R	DO41752	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.6457
p.P1283L	TCGA-AJ-A3EK	UCEC	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.1944
p.P1283L	DO41584	UCEC	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.1944
p.R1292H	TCGA-BR-7851	STAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.7133
p.R1292H	TCGA-D7-A6EY	STAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.7133
p.R1292H	DO50118	STAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.7133
p.R1292H	DO38711	STAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.7133
p.R1299W	TCGA-CM-6674	COAD	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299W	DO10092	COAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299W	SIDM00234	Other Solid Cancers	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299W	SIDM00281	Other Solid Cancers	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299W	SIDM00556	Neuroblastoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1299W	SIDM00511	Small Cell Lung Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.G1281C	TCGA-EB-A1NK	SKCM	TCGA	VGPFRE	LIG_APCC_ABBA_1	0.1389
p.G1281C	DO37695	SKCM	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.1389
p.R1303S	DO228976	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.0556
p.R1299L	DO229009	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.1667
p.R1292C	DO50757	LICA	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.719
p.R1292C	DO229114	PRAD	ICGC	VGPFRE	LIG_APCC_ABBA_1	0.719
p.R1292C	ACH-001518	Endometrial/Uterine Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	0.719
p.G1287A	SIDM00393	Gastric Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.3056
p.G1287A	ACH-001653	Gastric Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	0.3056
p.G1287A	SK-GT-2	stomach	COSMIC	VGPFRE	LIG_APCC_ABBA_1	0.3056
p.G1281D	SIDM00238	Ovarian Carcinoma	GDSC	VGPFRE	LIG_APCC_ABBA_1	0.1389
p.G1281D	ACH-000947	Ovarian Cancer	CCLE	VGPFRE	LIG_APCC_ABBA_1	0.1389
p.G1281D	OVK-18	ovary	COSMIC	VGPFRE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGPFRE

Degron related mutations and impact score

Drug responses associated with USP42 mutations

All proteins holding degron of VGPFRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	LIG_APCC_ABBA_1	1288:1293	VGPFRE	APC,CDC20,FZR1	0.562	More...