DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: DEG_SCF_FBW7_1

Location: 473:480

E3 ligase: FBXW7

DEGRON score: 0.9601

ASA_SCORE: 95.6

COIL: 0.9255

CONS_SCORE: 0.3092

DSS_SCORE: 0.7351

HELIX: 0.0445

FCONS_SCORE: 0.977

RIG_SCORE: 0.5835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S483N	DO228079	EOPC	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.6944
p.S480T	DO233058	GACA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.6005
p.G486W	DO229019	LICA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.1667
p.T476S	DO50819	LIRI	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.7116
p.N485S	DO222572	MELA	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.1944
p.T476M	DO41199	UCEC	ICGC	LKDTPSSS	DEG_SCF_FBW7_1	0.7423
p.G471V	ACH-002042	Thyroid Cancer	CCLE	LKDTPSSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SCF_FBW7_1	473:480	LKDTPSSS	FBXW7	0.9601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons