DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: LIG_APCC_ABBA_1

Location: 1125:1130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9207

ASA_SCORE: 88.8833

COIL: 0.8727

CONS_SCORE: 0.2381

DSS_SCORE: 0.6862

HELIX: 0.1027

FCONS_SCORE: 1.0274

RIG_SCORE: 0.5843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1130G	TCGA-AD-5900	COAD	TCGA	LAPHPD	LIG_APCC_ABBA_1	0.7198
p.D1130G	DO8514	COAD	ICGC	LAPHPD	LIG_APCC_ABBA_1	0.7198
p.R1136I	TCGA-AP-A059	UCEC	TCGA	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.R1136I	DO41361	UCEC	ICGC	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.R1131C	TCGA-AY-6197	COAD	TCGA	LAPHPD	LIG_APCC_ABBA_1	0.3056
p.R1131C	DO9956	COAD	ICGC	LAPHPD	LIG_APCC_ABBA_1	0.3056
p.A1119T	DO228308	MALY	ICGC	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.A1121T	SIDM02049	Pancreatic Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	0.2222
p.V1140L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	0.0556
p.V1140L	ACH-000843	Lung Cancer	CCLE	LAPHPD	LIG_APCC_ABBA_1	0.0556
p.V1140L	HARA	lung	COSMIC	LAPHPD	LIG_APCC_ABBA_1	0.0556
p.R1136K	SIDM00350	Head and Neck Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.R1136K	ACH-001641	Head and Neck Cancer	CCLE	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.R1136K	SAT	upper_aerodigestive_tract	COSMIC	LAPHPD	LIG_APCC_ABBA_1	0.1667
p.A1124T	SIDM00014	Colorectal Carcinoma	GDSC	LAPHPD	LIG_APCC_ABBA_1	0.3056
p.A1124T	LIM1215	large_intestine	COSMIC	LAPHPD	LIG_APCC_ABBA_1	0.3056
p.T1137N	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPHPD	LIG_APCC_ABBA_1	0.1389
p.T1137N	ACH-000920	Leukemia	CCLE	LAPHPD	LIG_APCC_ABBA_1	0.1389
p.T1137N	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPHPD	LIG_APCC_ABBA_1	0.1389
p.V1140I	CW-2	large_intestine	COSMIC	LAPHPD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	LIG_APCC_ABBA_1	1125:1130	LAPHPD	APC,CDC20,FZR1	0.9207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons