DegronMD

Uniprot ID: Q9H9J4

Source protein: Ubiquitin carboxyl-terminal hydrolase 42

Source gene: USP42

Class: DEG_APCC_KENBOX_2

Location: 623:627

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7408

ASA_SCORE: 91.74

COIL: 0.8292

CONS_SCORE: 0.2507

DSS_SCORE: 0.6719

HELIX: 0.1386

FCONS_SCORE: 0.8735

RIG_SCORE: 0.5984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E617K	TCGA-66-2795	LUSC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.1667
p.E617K	DO26710	LUSC	ICGC	GKENG	DEG_APCC_KENBOX_2	0.1667
p.E617K	SIDM00014	Colorectal Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	0.1667
p.E617K	LIM1215	large_intestine	COSMIC	GKENG	DEG_APCC_KENBOX_2	0.1667
p.G629D	TCGA-AX-A1CE	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.2778
p.G629D	DO42280	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	0.2778
p.I628N	TCGA-G4-6588	COAD	TCGA	GKENG	DEG_APCC_KENBOX_2	0.3056
p.I628N	DO10140	COAD	ICGC	GKENG	DEG_APCC_KENBOX_2	0.3056
p.I631T	DO233154	GACA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.2222
p.V632L	DO229025	LICA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.1944
p.G621V	DO232224	PBCA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.2778
p.H635L	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	0.1111
p.H635L	ACH-000747	Lung Cancer	CCLE	GKENG	DEG_APCC_KENBOX_2	0.1111
p.H635L	NCI-H1703	lung	COSMIC	GKENG	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_APCC_KENBOX_2	2745:2749	GKENG	APC,CDC20,FZR1	0.9366	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_APCC_KENBOX_2	623:627	GKENG	APC,CDC20,FZR1	0.7408	More...
A6NC57	Ankyrin repeat domain-containing protein 62	DEG_APCC_KENBOX_2	347:351	GKENG	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons