DegronMD

Uniprot ID: A6NC57

Source protein: Ankyrin repeat domain-containing protein 62

Source gene: ANKRD62

Class: DEG_APCC_KENBOX_2

Location: 347:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9971

ASA_SCORE: 81.2

COIL: 0.7102

CONS_SCORE: 0.6894

DSS_SCORE: 0.694

HELIX: 0.2704

FCONS_SCORE: 1.3064

RIG_SCORE: 0.5969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G351D	TCGA-EO-A3B0	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.6087
p.K359T	TCGA-EO-A3B0	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.2222
p.G337S	DO52639	BOCA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.0556
p.G337S	DO45129	LIRI	ICGC	GKENG	DEG_APCC_KENBOX_2	0.0556
p.T360M	DO227549	COCA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.0833
p.T360M	DO10900	GBM	ICGC	GKENG	DEG_APCC_KENBOX_2	0.0833
p.R344K	DO222595	MELA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.25
p.G337D	DO219773	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	0.0556
p.K345T	DO219773	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	0.2778
p.K339T	SIDM00193	Colorectal Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	0.2222
p.K339T	ACH-000991	Colon/Colorectal Cancer	CCLE	GKENG	DEG_APCC_KENBOX_2	0.2222
p.K339T	SNU-81	large_intestine	COSMIC	GKENG	DEG_APCC_KENBOX_2	0.2222
p.S345F	SIDM01066	Melanoma	GDSC	GKENG	DEG_APCC_KENBOX_2	0.2778
p.S345F	IGR-37	skin	COSMIC	GKENG	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_APCC_KENBOX_2	2745:2749	GKENG	APC,CDC20,FZR1	0.9366	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_APCC_KENBOX_2	623:627	GKENG	APC,CDC20,FZR1	0.7408	More...
A6NC57	Ankyrin repeat domain-containing protein 62	DEG_APCC_KENBOX_2	347:351	GKENG	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons