DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_APCC_KENBOX_2

Location: 2745:2749

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9366

ASA_SCORE: 89.28

COIL: 0.8928

CONS_SCORE: 0.4002

DSS_SCORE: 0.6859

HELIX: 0.0596

FCONS_SCORE: 1.1875

RIG_SCORE: 0.593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N2751S	TCGA-DI-A1BU	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.2778
p.R2746T	TCGA-PK-A5HC	ACC	TCGA	GKENG	DEG_APCC_KENBOX_2	0.7876
p.S2747C	DO49795	BLCA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.7541
p.K2741E	DO38909	THCA	ICGC	GKENG	DEG_APCC_KENBOX_2	0.2222
p.S2747Y	DO41644	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_APCC_KENBOX_2	2745:2749	GKENG	APC,CDC20,FZR1	0.9366	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_APCC_KENBOX_2	623:627	GKENG	APC,CDC20,FZR1	0.7408	More...
A6NC57	Ankyrin repeat domain-containing protein 62	DEG_APCC_KENBOX_2	347:351	GKENG	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons