DegronMD - A6NC57(ANKRD62)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D592Y	TCGA-AJ-A3EL	UCEC	TCGA	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.2222
p.D602A	TCGA-EO-A22R	UCEC	TCGA	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.2778
p.G351D	TCGA-EO-A3B0	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation altering degron motif	0.6087
p.K359T	TCGA-EO-A3B0	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation substituting flanking lysine	0.2222
p.G337S	DO52639	BOCA	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.0556
p.G337S	DO45129	LIRI	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.0556
p.A599T	DO228483	BRCA	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO229013	COCA	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO229005	COCA	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO234205	ESAD	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO229480	LAML	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO229489	LAML	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO230550	LUSC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.A599T	DO231049	LUSC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation altering degron motif	0.7139
p.T360M	DO227549	COCA	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.0833
p.T360M	DO10900	GBM	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.0833
p.Y607N	DO228903	LICA	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.1389
p.T601K	DO23496	LINC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.3056
p.T601K	DO45053	LINC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.3056
p.R344K	DO222595	MELA	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.25
p.G337D	DO219773	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.0556
p.K345T	DO219773	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.2778
p.K609E	DO43041	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.T605A	DO43907	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation substituting flanking lysine	0.3056
p.D588A	DO42713	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation substituting flanking lysine	0.2222
p.K339T	SIDM00193	Colorectal Carcinoma	GDSC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation substituting flanking lysine	0.2222
p.K339T	ACH-000991	Colon/Colorectal Cancer	CCLE	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation substituting flanking lysine	0.2222
p.K339T	SNU-81	large intestine	COSMIC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation substituting flanking lysine	0.2222
p.R609W	SIDM00878	Breast Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R609W	SIDM00879	Breast Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R609W	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R609W	HCC1500	breast	COSMIC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R609W	HCC1569	breast	COSMIC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.R609W	HCE-4	oesophagus	COSMIC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.0833
p.D592N	SIDM00450	Acute Myeloid Leukemia	GDSC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.2222
p.D592N	ACH-000218	Leukemia	CCLE	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.2222
p.D592N	PL-21	haematopoietic and lymphoid tissue	COSMIC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.2222
p.L603H	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.25
p.L603H	ACH-000611	Lymphoma	CCLE	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.25
p.L603H	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	IKENN	DEG_APCC_KENBOX_2	596:600	Mutation rewiring degron network	0.25
p.S345F	SIDM01066	Melanoma	GDSC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.2778
p.S345F	IGR-37	skin	COSMIC	GKENG	DEG_APCC_KENBOX_2	347:351	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD62

UniProt ID: A6NC57

Entrez ID: 342850

Protein name: Ankyrin repeat domain-containing protein 62

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD62 in