DegronMD

Uniprot ID: A6NC57

Source protein: Ankyrin repeat domain-containing protein 62

Source gene: ANKRD62

Class: DEG_APCC_KENBOX_2

Location: 596:600

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7559

ASA_SCORE: 93.76

COIL: 0.0606

CONS_SCORE: 0.6865

DSS_SCORE: 0.2395

HELIX: 0.9408

FCONS_SCORE: 1.1905

RIG_SCORE: 0.8014

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D592Y	TCGA-AJ-A3EL	UCEC	TCGA	IKENN	DEG_APCC_KENBOX_2	0.2222
p.D602A	TCGA-EO-A22R	UCEC	TCGA	IKENN	DEG_APCC_KENBOX_2	0.2778
p.A599T	DO228483	BRCA	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO229013	COCA	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO229005	COCA	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO234205	ESAD	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO229480	LAML	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO229489	LAML	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO230550	LUSC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.A599T	DO231049	LUSC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.7139
p.Y607N	DO228903	LICA	ICGC	IKENN	DEG_APCC_KENBOX_2	0.1389
p.T601K	DO23496	LINC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.3056
p.T601K	DO45053	LINC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.3056
p.K609E	DO43041	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.T605A	DO43907	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.3056
p.D588A	DO42713	UCEC	ICGC	IKENN	DEG_APCC_KENBOX_2	0.2222
p.R609W	SIDM00878	Breast Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.R609W	SIDM00879	Breast Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.R609W	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.R609W	HCC1500	breast	COSMIC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.R609W	HCC1569	breast	COSMIC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.R609W	HCE-4	oesophagus	COSMIC	IKENN	DEG_APCC_KENBOX_2	0.0833
p.D592N	SIDM00450	Acute Myeloid Leukemia	GDSC	IKENN	DEG_APCC_KENBOX_2	0.2222
p.D592N	ACH-000218	Leukemia	CCLE	IKENN	DEG_APCC_KENBOX_2	0.2222
p.D592N	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	IKENN	DEG_APCC_KENBOX_2	0.2222
p.L603H	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKENN	DEG_APCC_KENBOX_2	0.25
p.L603H	ACH-000611	Lymphoma	CCLE	IKENN	DEG_APCC_KENBOX_2	0.25
p.L603H	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	IKENN	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKENN

Degron related mutations and impact score

Drug responses associated with ANKRD62 mutations

All proteins holding degron of IKENN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NC57	Ankyrin repeat domain-containing protein 62	DEG_APCC_KENBOX_2	596:600	IKENN	APC,CDC20,FZR1	0.7559	More...