DegronMD

Uniprot ID: O60307

Source protein: Microtubule-associated serine/threonine-protein kinase 3

Source gene: MAST3

Class: DEG_SPOP_SBC_1

Location: 707:711

E3 ligase: SPOP

DEGRON score: 0.9777

ASA_SCORE: 58.6

COIL: 0.6734

CONS_SCORE: 0.3627

DSS_SCORE: 0.3158

HELIX: 0.248

FCONS_SCORE: 0.9961

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S701F	TCGA-21-1079	LUSC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1667
p.S701F	DO26846	LUSC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1667
p.P718S	TCGA-2W-A8YY	CESC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.1389
p.P718S	DO223732	CESC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1389
p.A715V	TCGA-BS-A0U8	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2222
p.A715V	TCGA-E6-A2P9	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	0.2222
p.A715V	DO43714	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.A715V	DO41380	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.C700F	DO228948	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1389
p.H702R	DO220886	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.1944
p.E712K	DO229213	THCA	ICGC	VYSSS	DEG_SPOP_SBC_1	0.3056
p.T721A	SIDM00334	Endometrial Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.T721A	ACH-000879	Endometrial/Uterine Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	0.0556
p.T721A	MFE-296	endometrium	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.0556
p.R703Q	SIDM00884	Breast Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	0.2222
p.R703Q	ACH-000699	Breast Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	0.2222
p.R703Q	HCC1395	breast	COSMIC	VYSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	707:711	VYSSS	SPOP	0.9777	More...
O75494	Serine/arginine-rich splicing factor 10	DEG_SPOP_SBC_1	104:108	VYSSS	SPOP	0.9991	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	602:606	VYSSS	SPOP	0.7963	More...
Q8IZJ1	Netrin receptor UNC5B	DEG_SPOP_SBC_1	484:488	VYSSS	SPOP	0.9604	More...
Q92753	Nuclear receptor ROR-beta	DEG_SPOP_SBC_1	132:136	VYSSS	SPOP	0.5622	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	62:66	VYSSS	SPOP	0.9965	More...
Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	DEG_SPOP_SBC_1	650:654	VYSSS	SPOP	0.9994	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1303:1307	VYSSS	SPOP	0.6435	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6282	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9981	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.9754	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SPOP_SBC_1	1195:1199	VYSSS	SPOP	0.982	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SPOP_SBC_1	1199:1203	VYSSS	SPOP	0.6896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons