DegronMD - O60307(MAST3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L113I	TCGA-06-5416	GBM	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7174
p.L113I	DO10880	GBM	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7174
p.S701F	TCGA-21-1079	LUSC	TCGA	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.S701F	DO26846	LUSC	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.P718S	TCGA-2W-A8YY	CESC	TCGA	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1389
p.P718S	DO223732	CESC	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1389
p.P1127S	TCGA-44-8120	LUAD	TCGA	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.25
p.P1127S	DO45402	LUAD	ICGC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.25
p.L86I	TCGA-66-2734	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7174
p.L86I	TCGA-EE-A20C	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7174
p.L86I	DO26430	LUSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7174
p.L86I	DO47665	SKCM	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7174
p.G93S	TCGA-AX-A2HA	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.G93S	DO42504	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.D123N	TCGA-B5-A3FC	UCEC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.D123N	DO41871	UCEC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.A715V	TCGA-BS-A0U8	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.A715V	TCGA-E6-A2P9	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.A715V	DO43714	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.A715V	DO41380	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.G1154D	TCGA-CK-4951	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.1111
p.G1154D	DO10582	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.1111
p.S104L	TCGA-DC-5869	READ	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1944
p.P99L	TCGA-DF-A2KU	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.P99L	TCGA-DF-A2KU	UCEC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0556
p.P99L	DO223286	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.P99L	DO223286	UCEC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0556
p.H114N	TCGA-EE-A3JD	SKCM	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6312
p.H114N	DO50299	SKCM	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6312
p.T37M	TCGA-FI-A2D0	UCEC	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation altering degron motif	0.8534
p.T37M	DO43891	UCEC	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation altering degron motif	0.8534
p.K31N	TCGA-FS-A1ZP	SKCM	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation substituting flanking lysine	0.3611
p.K31N	DO37703	SKCM	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation substituting flanking lysine	0.3611
p.A1140T	TCGA-G2-A2EL	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.A1140T	DO478	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.S107L	TCGA-JX-A3Q8	CESC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2778
p.S107L	DO51608	CESC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2778
p.S47L	TCGA-SJ-A6ZI	UCEC	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation blocking phosphorylation signal	0.6111
p.S47L	DO219784	UCEC	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation blocking phosphorylation signal	0.6111
p.R110Q	TCGA-VQ-A924	STAD	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7329
p.R110Q	DO51795	STAD	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7329
p.S108F	TCGA-ZF-A9RC	BLCA	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.3056
p.S108F	DO219068	BLCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.3056
p.L113F	TCGA-ZF-A9RC	BLCA	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6981
p.L113F	DO219068	BLCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6981
p.R30H	DO222574	BTCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.2222
p.R30H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.2222
p.R30H	ACH-000874	Leukemia	CCLE	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.2222
p.R30H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.2222
p.S101F	DO222728	BTCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.S101F	DO23094	LINC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.V51I	DO227646	COCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.0556
p.R26H	DO234462	ESAD	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.R26H	DO232761	PBCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.R26C	DO233260	GACA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.S27N	DO233944	GACA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1389
p.C700F	DO228948	LICA	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1389
p.S1113I	DO228985	LICA	ICGC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1944
p.A1140S	DO229018	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.V51F	DO229034	LICA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.0556
p.R44L	DO229009	LICA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.25
p.H702R	DO220886	MELA	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1944
p.A1131E	DO232009	ORCA	ICGC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1389
p.V35I	DO46566	OV	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation altering degron motif	0.5965
p.H126P	DO35172	PACA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.0833
p.T1120P	DO48554	PAEN	ICGC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation altering degron motif	0.7031
p.E712K	DO229213	THCA	ICGC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.3056
p.V34L	DO230449	UTCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation altering degron motif	0.5654
p.A1148V	SIDM00422	Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.A1148V	ACH-001203	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.A1148V	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.S106N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.S106N	ACH-000981	Leukemia	CCLE	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.S106N	DND-41	haematopoietic and lymphoid tissue	COSMIC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.T721A	SIDM00334	Endometrial Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.0556
p.T721A	ACH-000879	Endometrial/Uterine Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.0556
p.T721A	MFE-296	endometrium	COSMIC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.0556
p.A1152D	SIDM00924	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.1667
p.A1152D	ACH-000867	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.1667
p.R77W	SIDM00251	Gastric Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.R77W	ACH-000949	Gastric Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.R77W	TGBC11TKB	stomach	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.R26G	SIDM00357	Small Cell Lung Carcinoma	GDSC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.R26G	ACH-002193	Lung Cancer	CCLE	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.R26G	RERF-LC-FM	lung	COSMIC	VVGTPSPT	DEG_SCF_FBW7_1	34:41	Mutation rewiring degron network	0.1111
p.R703Q	SIDM00884	Breast Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.R703Q	ACH-000699	Breast Cancer	CCLE	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.R703Q	HCC1395	breast	COSMIC	VYSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.D1132V	SIDM00239	Kidney Carcinoma	GDSC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1111
p.D1132V	SIDM00239	Kidney Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.0556
p.D1132V	OS-RC-2	kidney	COSMIC	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1111
p.D1132V	OS-RC-2	kidney	COSMIC	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.0556
p.R112C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.719
p.R112C	ACH-000964	Leukemia	CCLE	SRERLHQLP	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.719
p.A1148P	ACH-000036	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1142:1146	Mutation rewiring degron network	0.2778
p.T1111P	ACH-002148	Thyroid Cancer	CCLE	PTTPCRS	DEG_SCF_FBW7_1	1118:1124	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAST3

UniProt ID: O60307

Entrez ID: 23031

Protein name: Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAST3 in