DegronMD

Uniprot ID: O60307

Source protein: Microtubule-associated serine/threonine-protein kinase 3

Source gene: MAST3

Class: DEG_SCF_FBW7_1

Location: 34:41

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 78.1625

COIL: 0.8693

CONS_SCORE: 0.3263

DSS_SCORE: 0.5989

HELIX: 0.018

FCONS_SCORE: 0.9148

RIG_SCORE: 0.6426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T37M	TCGA-FI-A2D0	UCEC	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	0.8534
p.T37M	DO43891	UCEC	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.8534
p.K31N	TCGA-FS-A1ZP	SKCM	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	0.3611
p.K31N	DO37703	SKCM	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.3611
p.S47L	TCGA-SJ-A6ZI	UCEC	TCGA	VVGTPSPT	DEG_SCF_FBW7_1	0.6111
p.S47L	DO219784	UCEC	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.6111
p.R30H	DO222574	BTCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.2222
p.R30H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VVGTPSPT	DEG_SCF_FBW7_1	0.2222
p.R30H	ACH-000874	Leukemia	CCLE	VVGTPSPT	DEG_SCF_FBW7_1	0.2222
p.R30H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VVGTPSPT	DEG_SCF_FBW7_1	0.2222
p.V51I	DO227646	COCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.0556
p.R26H	DO234462	ESAD	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.1111
p.R26H	DO232761	PBCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.1111
p.R26C	DO233260	GACA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.1111
p.S27N	DO233944	GACA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.1389
p.V51F	DO229034	LICA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.0556
p.R44L	DO229009	LICA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.25
p.V35I	DO46566	OV	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.5965
p.V34L	DO230449	UTCA	ICGC	VVGTPSPT	DEG_SCF_FBW7_1	0.5654
p.R26G	SIDM00357	Small Cell Lung Carcinoma	GDSC	VVGTPSPT	DEG_SCF_FBW7_1	0.1111
p.R26G	ACH-002193	Lung Cancer	CCLE	VVGTPSPT	DEG_SCF_FBW7_1	0.1111
p.R26G	RERF-LC-FM	lung	COSMIC	VVGTPSPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SCF_FBW7_1	34:41	VVGTPSPT	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons