DegronMD

Uniprot ID: O60307

Source protein: Microtubule-associated serine/threonine-protein kinase 3

Source gene: MAST3

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8625

ASA_SCORE: 62.6444

COIL: 0.5752

CONS_SCORE: 0.5086

DSS_SCORE: 0.4329

HELIX: 0.0986

FCONS_SCORE: 1.2159

RIG_SCORE: 0.7163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L86I	TCGA-66-2734	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.7174
p.L86I	TCGA-EE-A20C	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.7174
p.L86I	DO26430	LUSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.7174
p.L86I	DO47665	SKCM	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.7174
p.G93S	TCGA-AX-A2HA	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.G93S	DO42504	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.P99L	TCGA-DF-A2KU	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.P99L	DO223286	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.R77W	SIDM00251	Gastric Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.R77W	ACH-000949	Gastric Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.R77W	TGBC11TKB	stomach	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_APCC_DBOX_1	282:290	RRWSLASLP	APC,CDC20,FZR1	0.9866	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	82:90	RRWSLASLP	APC,CDC20,FZR1	0.8625	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	227:235	RRWSLASLP	APC,CDC20,FZR1	0.978	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_APCC_DBOX_1	87:95	RRWSLASLP	APC,CDC20,FZR1	0.7322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons