DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_APCC_DBOX_1

Location: 227:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.978

ASA_SCORE: 61.6111

COIL: 0.6508

CONS_SCORE: 0.5045

DSS_SCORE: 0.5079

HELIX: 0.0891

FCONS_SCORE: 1.2463

RIG_SCORE: 0.7226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R222C	TCGA-90-A4ED	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.R222C	DO230312	COCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.R222C	DO45482	LUSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.P235L	TCGA-B5-A1MX	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.6471
p.P235L	DO41999	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.6471
p.S230A	TCGA-NJ-A4YI	LUAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.7588
p.S230A	DO218942	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.7588
p.R227W	DO234315	ESAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.7523
p.R228C	DO225448	GACA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.8301
p.R222H	DO229056	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_APCC_DBOX_1	282:290	RRWSLASLP	APC,CDC20,FZR1	0.9866	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	82:90	RRWSLASLP	APC,CDC20,FZR1	0.8625	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	227:235	RRWSLASLP	APC,CDC20,FZR1	0.978	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_APCC_DBOX_1	87:95	RRWSLASLP	APC,CDC20,FZR1	0.7322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons