DegronMD

Uniprot ID: O15021

Source protein: Microtubule-associated serine/threonine-protein kinase 4

Source gene: MAST4

Class: DEG_APCC_DBOX_1

Location: 282:290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9866

ASA_SCORE: 72.4111

COIL: 0.6283

CONS_SCORE: 0.4773

DSS_SCORE: 0.4813

HELIX: 0.1468

FCONS_SCORE: 1.273

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R283H	TCGA-56-5897	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.8244
p.R278W	TCGA-B0-5098	KIRC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.2222
p.A287D	TCGA-B5-A3FC	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.6682
p.R278S	TCGA-DD-AACZ	LIHC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.2222
p.S285W	TCGA-DD-AADV	LIHC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.7874
p.S285W	TCGA-W5-AA2U	CHOL	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.7874
p.P299H	TCGA-DZ-6133	KIRP	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.W284L	TCGA-EE-A29L	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.5904
p.A276S	TCGA-K4-A5RJ	BLCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1667
p.S274L	TCGA-Z2-A8RT	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.S274L	SIDM00527	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.S274L	ACH-000935	Colon/Colorectal Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.S274L	MDST8	large_intestine	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.R299C	DO223732	CESC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.K292T	DO8400	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.2778
p.D276Y	DO229027	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1667
p.A274T	DO25471	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.R299L	DO23771	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.R277C	DO42312	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.E282K	DO41211	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.7022
p.R278G	SIDM00150	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	0.2222
p.R278G	KM12	large_intestine	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_APCC_DBOX_1	282:290	RRWSLASLP	APC,CDC20,FZR1	0.9866	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	82:90	RRWSLASLP	APC,CDC20,FZR1	0.8625	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	227:235	RRWSLASLP	APC,CDC20,FZR1	0.978	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_APCC_DBOX_1	87:95	RRWSLASLP	APC,CDC20,FZR1	0.7322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons