DegronMD

Uniprot ID: O60307

Source protein: Microtubule-associated serine/threonine-protein kinase 3

Source gene: MAST3

Class: DEG_APCC_DBOX_1

Location: 109:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 101

COIL: 0.7264

CONS_SCORE: 0.4953

DSS_SCORE: 0.6459

HELIX: 0.2222

FCONS_SCORE: 1.217

RIG_SCORE: 0.6417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L113I	TCGA-06-5416	GBM	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.7174
p.L113I	DO10880	GBM	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.7174
p.D123N	TCGA-B5-A3FC	UCEC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.1667
p.D123N	DO41871	UCEC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.1667
p.S104L	TCGA-DC-5869	READ	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.1944
p.P99L	TCGA-DF-A2KU	UCEC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.0556
p.P99L	DO223286	UCEC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.0556
p.H114N	TCGA-EE-A3JD	SKCM	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.6312
p.H114N	DO50299	SKCM	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.6312
p.S107L	TCGA-JX-A3Q8	CESC	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.2778
p.S107L	DO51608	CESC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.2778
p.R110Q	TCGA-VQ-A924	STAD	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.7329
p.R110Q	DO51795	STAD	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.7329
p.S108F	TCGA-ZF-A9RC	BLCA	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.3056
p.S108F	DO219068	BLCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.3056
p.L113F	TCGA-ZF-A9RC	BLCA	TCGA	SRERLHQLP	DEG_APCC_DBOX_1	0.6981
p.L113F	DO219068	BLCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.6981
p.S101F	DO222728	BTCA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.1111
p.S101F	DO23094	LINC	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.1111
p.H126P	DO35172	PACA	ICGC	SRERLHQLP	DEG_APCC_DBOX_1	0.0833
p.S106N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRERLHQLP	DEG_APCC_DBOX_1	0.25
p.S106N	ACH-000981	Leukemia	CCLE	SRERLHQLP	DEG_APCC_DBOX_1	0.25
p.S106N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SRERLHQLP	DEG_APCC_DBOX_1	0.25
p.R112C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SRERLHQLP	DEG_APCC_DBOX_1	0.719
p.R112C	ACH-000964	Leukemia	CCLE	SRERLHQLP	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	109:117	SRERLHQLP	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRERLHQLP

Degron related mutations and impact score

Drug responses associated with MAST3 mutations

All proteins holding degron of SRERLHQLP