DegronMD

Uniprot ID: O60307

Source protein: Microtubule-associated serine/threonine-protein kinase 3

Source gene: MAST3

Class: DEG_SCF_FBW7_1

Location: 1118:1124

E3 ligase: FBXW7

DEGRON score: 0.9187

ASA_SCORE: 95.3571

COIL: 0.9673

CONS_SCORE: 0.3482

DSS_SCORE: 0.7144

HELIX: 0.0109

FCONS_SCORE: 0.9956

RIG_SCORE: 0.545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1127S	TCGA-44-8120	LUAD	TCGA	PTTPCRS	DEG_SCF_FBW7_1	0.25
p.P1127S	DO45402	LUAD	ICGC	PTTPCRS	DEG_SCF_FBW7_1	0.25
p.S1113I	DO228985	LICA	ICGC	PTTPCRS	DEG_SCF_FBW7_1	0.1944
p.A1131E	DO232009	ORCA	ICGC	PTTPCRS	DEG_SCF_FBW7_1	0.1389
p.T1120P	DO48554	PAEN	ICGC	PTTPCRS	DEG_SCF_FBW7_1	0.7031
p.D1132V	SIDM00239	Kidney Carcinoma	GDSC	PTTPCRS	DEG_SCF_FBW7_1	0.1111
p.D1132V	OS-RC-2	kidney	COSMIC	PTTPCRS	DEG_SCF_FBW7_1	0.1111
p.T1111P	ACH-002148	Thyroid Cancer	CCLE	PTTPCRS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SCF_FBW7_1	1118:1124	PTTPCRS	FBXW7	0.9187	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons