DegronMD

Uniprot ID: Q92753

Source protein: Nuclear receptor ROR-beta

Source gene: RORB

Class: DEG_SCF_TRCP1_1

Location: 170:175

E3 ligase: BTRC

DEGRON score: 0.9915

ASA_SCORE: 55.6

COIL: 0.915

CONS_SCORE: 0.4133

DSS_SCORE: 0.6411

HELIX: 0.0305

FCONS_SCORE: 1.034

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D171E	TCGA-14-0736	GBM	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.6758
p.D171E	DO10875	GBM	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.6758
p.S160F	TCGA-CA-6717	COAD	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.0556
p.S160F	DO8264	COAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.0556
p.P165S	TCGA-EB-A41A	SKCM	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.1944
p.P165S	DO234401	ESAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1944
p.P165S	DO37429	SKCM	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1944
p.S164F	TCGA-EM-A2CM	THCA	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.1667
p.S164F	DO39228	THCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1667
p.G174A	DO1098	BRCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.754
p.Q167H	DO229038	LICA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.25
p.M172V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGQPS	DEG_SCF_TRCP1_1	0.7208
p.M172V	ACH-000924	Lung Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	0.7208
p.M172V	NCI-H2172	lung	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	0.7208
p.G165S	U-118-MG	central_nervous_system	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	0.1944
p.M183V	NCI-H2172	lung	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	52:57	DSGQPS	BTRC	0.96	More...
Q92753	Nuclear receptor ROR-beta	DEG_SCF_TRCP1_1	170:175	DSGQPS	BTRC	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons