DegronMD

Uniprot ID: Q8WVC0

Source protein: RNA polymerase-associated protein LEO1

Source gene: LEO1

Class: DEG_SCF_TRCP1_1

Location: 52:57

E3 ligase: BTRC

DEGRON score: 0.96

ASA_SCORE: 87

COIL: 0.9522

CONS_SCORE: 0.2514

DSS_SCORE: 0.8919

HELIX: 0.034

FCONS_SCORE: 0.7294

RIG_SCORE: 0.5012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D64N	TCGA-55-6968	LUAD	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.1389
p.D64N	DO23759	LUAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1389
p.E44A	TCGA-EY-A1GI	UCEC	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.E44A	DO41211	UCEC	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.D65N	TCGA-YC-A8S6	BLCA	TCGA	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.D65N	DO49806	BLCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.D65E	DO229025	LICA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.N58S	DO34448	PACA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.3056
p.N58T	DO232224	PBCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	0.3056
p.E44K	SIDM00150	Colorectal Carcinoma	GDSC	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.E44K	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.E44K	KM12	large_intestine	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	0.1111
p.D46Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	52:57	DSGQPS	BTRC	0.96	More...
Q92753	Nuclear receptor ROR-beta	DEG_SCF_TRCP1_1	170:175	DSGQPS	BTRC	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons