DegronMD - Q8WVC0(LEO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D64N	TCGA-55-6968	LUAD	TCGA	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1389
p.D64N	DO23759	LUAD	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1389
p.S23T	TCGA-AG-3902	READ	TCGA	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation altering degron motif	0.8227
p.S23T	DO36407	READ	ICGC	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation altering degron motif	0.8227
p.E15K	TCGA-BH-A0B6	BRCA	TCGA	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.1389
p.E15K	DO2641	BRCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.1389
p.S23F	TCGA-BH-A0HF	BRCA	TCGA	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation altering degron motif	0.9093
p.S23F	DO1749	BRCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	22:27	Mutation altering degron motif	0.9093
p.E44A	TCGA-EY-A1GI	UCEC	TCGA	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.E44A	DO41211	UCEC	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.D65N	TCGA-YC-A8S6	BLCA	TCGA	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.D65N	DO49806	BLCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.D65E	DO229025	LICA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.N58S	DO34448	PACA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.3056
p.N58T	DO232224	PBCA	ICGC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.3056
p.E44K	SIDM00150	Colorectal Carcinoma	GDSC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.E44K	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.E44K	KM12	large intestine	COSMIC	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1111
p.D46Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGQPS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1667

Kaplan plot for LEO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LEO1

UniProt ID: Q8WVC0

Entrez ID: 123169

Protein name: RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LEO1 in