DegronMD

Uniprot ID: Q8WVC0

Source protein: RNA polymerase-associated protein LEO1

Source gene: LEO1

Class: DEG_SCF_TRCP1_1

Location: 22:27

E3 ligase: BTRC

DEGRON score: 0.9469

ASA_SCORE: 91.3333

COIL: 0.9658

CONS_SCORE: 0.2207

DSS_SCORE: 0.8502

HELIX: 0.0267

FCONS_SCORE: 0.7973

RIG_SCORE: 0.4939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S23T	TCGA-AG-3902	READ	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.8227
p.S23T	DO36407	READ	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.8227
p.E15K	TCGA-BH-A0B6	BRCA	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.1389
p.E15K	DO2641	BRCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.1389
p.S23F	TCGA-BH-A0HF	BRCA	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.9093
p.S23F	DO1749	BRCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.9093

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_SCF_TRCP1_1	479:484	DSGSDS	BTRC	0.987	More...
Q6PI26	Protein SHQ1 homolog	DEG_SCF_TRCP1_1	470:475	DSGSDS	BTRC	0.7439	More...
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	22:27	DSGSDS	BTRC	0.9469	More...
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	620:625	DSGSDS	BTRC	0.9983	More...
Q9UPA5	Protein bassoon	DEG_SCF_TRCP1_1	2638:2643	DSGSDS	BTRC	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons