DegronMD

Uniprot ID: P30203

Source protein: T-cell differentiation antigen CD6

Source gene: CD6

Class: DEG_SCF_TRCP1_1

Location: 479:484

E3 ligase: BTRC

DEGRON score: 0.987

ASA_SCORE: 73.3

COIL: 0.8852

CONS_SCORE: 0.8477

DSS_SCORE: 0.7578

HELIX: 0.086

FCONS_SCORE: 1.0547

RIG_SCORE: 0.5549

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S482L	TCGA-BR-A4J2	STAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.7667
p.G481D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.G481D	SIDM00930	Osteosarcoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.Y486F	TCGA-49-6767	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.2778
p.R477Q	DO229470	SKCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2778
p.R477Q	DO42280	UCEC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2778
p.R477W	DO48174	UCEC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2778
p.E476K	SIDM00007	Other Solid Cancers	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.E476K	ACH-001550	Skin Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.E476K	MCC13	skin	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.R475L	DO229038	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.R475W	DO229250	THCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P473L	TCGA-B5-A11Y	UCEC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.1667

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	620:625	DSGSDS	BTRC	0.9983	More...
Q9UPA5	Protein bassoon	DEG_SCF_TRCP1_1	2638:2643	DSGSDS	BTRC	0.9935	More...
Q6PI26	Protein SHQ1 homolog	DEG_SCF_TRCP1_1	470:475	DSGSDS	BTRC	0.7439	More...
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	22:27	DSGSDS	BTRC	0.9469	More...
P30203	T-cell differentiation antigen CD6	DEG_SCF_TRCP1_1	479:484	DSGSDS	BTRC	0.987	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons