DegronMD - P30203(CD6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H557Y	TCGA-05-4395	LUAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.1111
p.G569W	TCGA-43-2581	LUSC	TCGA	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation altering degron motif	0.7825
p.Y486F	TCGA-49-6767	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2778
p.P473L	TCGA-B5-A11Y	UCEC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.1667
p.S482L	TCGA-BR-A4J2	STAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation altering degron motif	0.7667
p.S568L	TCGA-DK-A2I1	BLCA	TCGA	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation altering degron motif	0.8778
p.P634S	TCGA-F1-6177	STAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1389
p.P634S	DO38727	STAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1389
p.S612A	TCGA-FP-A4BF	STAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.0556
p.P558S	TCGA-FW-A3R5	SKCM	TCGA	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.1389
p.S625F	TCGA-FW-A3R5	SKCM	TCGA	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation altering degron motif	0.7982
p.G626R	TCGA-LN-A49Y	ESCA	TCGA	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation altering degron motif	0.7568
p.A573T	DO51206	BRCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.25
p.A573T	DO17937	KIRC	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.25
p.P616L	DO230326	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1667
p.P616L	DO229264	THCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1667
p.G574S	DO229013	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.2222
p.G574S	DO229005	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.2222
p.G574S	DO229059	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.2222
p.L570V	DO234333	ESAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation altering degron motif	0.6765
p.P616Q	DO231959	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1667
p.A635S	DO229019	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1111
p.R475L	DO229038	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2222
p.G613V	DO229041	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.0833
p.D626E	DO25471	LUAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation altering degron motif	0.6758
p.P618H	DO24850	LUAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.2222
p.S562F	DO222753	MELA	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation blocking phosphorylation signal	0.6944
p.S562F	DO47569	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation blocking phosphorylation signal	0.6944
p.A635E	DO50708	ORCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.1111
p.Q576K	DO28018	OV	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.1667
p.Q576K	DO47706	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.1667
p.R477Q	DO229470	SKCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2778
p.R477Q	DO42280	UCEC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2778
p.P568S	DO50301	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation altering degron motif	0.6752
p.S557F	DO47700	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.1111
p.D628N	DO48667	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.3056
p.S580A	DO47775	STAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.0556
p.R475W	DO229250	THCA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2222
p.R477W	DO48174	UCEC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.2778
p.S619N	DO43017	UCEC	ICGC	STSSGE	DEG_Kelch_Keap1_1	622:627	Mutation rewiring degron network	0.25
p.E476K	SIDM00007	Other Solid Cancers	GDSC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.25
p.E476K	ACH-001550	Skin Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.25
p.E476K	MCC13	skin	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation rewiring degron network	0.25
p.S560N	SIDM00370	T-Lymphoblastic Leukemia	GDSC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation blocking phosphorylation signal	0.6389
p.S560N	ACH-000197	Leukemia	CCLE	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation blocking phosphorylation signal	0.6389
p.S560N	TALL-1	haematopoietic and lymphoid tissue	COSMIC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation blocking phosphorylation signal	0.6389
p.G481D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation altering degron motif	0.7198
p.G481D	SIDM00930	Osteosarcoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	479:484	Mutation altering degron motif	0.7198
p.S564L	SIDM00217	Colorectal Carcinoma	GDSC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.3056
p.S564L	SNU-1040	large intestine	COSMIC	STSSGE	DEG_Kelch_Keap1_1	565:570	Mutation rewiring degron network	0.3056

Kaplan plot for CD6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD6

UniProt ID: P30203

Entrez ID: 923

Protein name: T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD6 in