DegronMD

Uniprot ID: P30203

Source protein: T-cell differentiation antigen CD6

Source gene: CD6

Class: DEG_Kelch_Keap1_1

Location: 565:570

E3 ligase: KEAP1

DEGRON score: 0.9993

ASA_SCORE: 71.9333

COIL: 0.8553

CONS_SCORE: 0.8955

DSS_SCORE: 0.6568

HELIX: 0.0947

FCONS_SCORE: 1.2052

RIG_SCORE: 0.5331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H557Y	TCGA-05-4395	LUAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.1111
p.G569W	TCGA-43-2581	LUSC	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.7825
p.S568L	TCGA-DK-A2I1	BLCA	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.8778
p.P558S	TCGA-FW-A3R5	SKCM	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.1389
p.A573T	DO51206	BRCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.25
p.A573T	DO17937	KIRC	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.25
p.G574S	DO229013	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.2222
p.G574S	DO229005	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.2222
p.G574S	DO229059	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.2222
p.L570V	DO234333	ESAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.6765
p.S562F	DO222753	MELA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.6944
p.S562F	DO47569	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.6944
p.Q576K	DO28018	OV	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1667
p.Q576K	DO47706	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1667
p.P568S	DO50301	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.6752
p.S557F	DO47700	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1111
p.S580A	DO47775	STAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.0556
p.S560N	SIDM00370	T-Lymphoblastic Leukemia	GDSC	STSSGE	DEG_Kelch_Keap1_1	0.6389
p.S560N	ACH-000197	Leukemia	CCLE	STSSGE	DEG_Kelch_Keap1_1	0.6389
p.S560N	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	STSSGE	DEG_Kelch_Keap1_1	0.6389
p.S564L	SIDM00217	Colorectal Carcinoma	GDSC	STSSGE	DEG_Kelch_Keap1_1	0.3056
p.S564L	SNU-1040	large_intestine	COSMIC	STSSGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_Kelch_Keap1_1	565:570	STSSGE	KEAP1	0.9993	More...
P30203	T-cell differentiation antigen CD6	DEG_Kelch_Keap1_1	622:627	STSSGE	KEAP1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons