DegronMD

Uniprot ID: P30203

Source protein: T-cell differentiation antigen CD6

Source gene: CD6

Class: DEG_Kelch_Keap1_1

Location: 622:627

E3 ligase: KEAP1

DEGRON score: 0.9957

ASA_SCORE: 68.5833

COIL: 0.814

CONS_SCORE: 1

DSS_SCORE: 0.8142

HELIX: 0.1215

FCONS_SCORE: 1.169

RIG_SCORE: 0.556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P634S	TCGA-F1-6177	STAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.1389
p.P634S	DO38727	STAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1389
p.S612A	TCGA-FP-A4BF	STAD	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.0556
p.S625F	TCGA-FW-A3R5	SKCM	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.7982
p.G626R	TCGA-LN-A49Y	ESCA	TCGA	STSSGE	DEG_Kelch_Keap1_1	0.7568
p.P616L	DO230326	COCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1667
p.P616L	DO229264	THCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1667
p.P616Q	DO231959	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1667
p.A635S	DO229019	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1111
p.G613V	DO229041	LICA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.0833
p.D626E	DO25471	LUAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.6758
p.P618H	DO24850	LUAD	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.2222
p.A635E	DO50708	ORCA	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.1111
p.D628N	DO48667	SKCM	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.3056
p.S619N	DO43017	UCEC	ICGC	STSSGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_Kelch_Keap1_1	565:570	STSSGE	KEAP1	0.9993	More...
P30203	T-cell differentiation antigen CD6	DEG_Kelch_Keap1_1	622:627	STSSGE	KEAP1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons