DegronMD - Q6PI26(SHQ1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D470H	TCGA-05-5425	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.7688
p.D474Y	TCGA-19-5956	GBM	TCGA	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.6214
p.D474E	TCGA-38-4632	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.5647
p.D122N	TCGA-A5-A0G1	UCEC	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.1389
p.W127C	TCGA-CV-A6K1	HNSC	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.2778
p.W127C	DO52078	HNSC	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.2778
p.S138L	TCGA-EB-A6QY	SKCM	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.2778
p.S138L	DO48702	SKCM	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.2778
p.E469Q	TCGA-N5-A4RJ	UCS	TCGA	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.3056
p.D482Y	DO7066	CLLE	ICGC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1389
p.L137M	DO228976	LICA	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.3056
p.D470E	DO229025	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.6758
p.S461R	DO26429	LUSC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.0833
p.E470K	DO48601	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.7022
p.P466L	DO38051	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.2222
p.P466L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.2222
p.P466L	U-266	haematopoietic and lymphoid tissue	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.2222
p.D139G	DO41542	UCEC	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.25
p.C134Y	SIDM00969	Ovarian Carcinoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.5976
p.C134Y	SIDM00087	Plasma Cell Myeloma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.5976
p.C134Y	SIDM00793	Burkitt's Lymphoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.5976
p.C134Y	SIDM00068	Colorectal Carcinoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.5976
p.C134Y	SIDM01525	Acute Myeloid Leukemia	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.5976
p.G123E	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.1667
p.G121E	AN3-CA	endometrium	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.1111
p.V140G	SW684	soft tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.2222
p.H119Y	TGBC11TKB	stomach	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation rewiring degron network	0.0556
p.S462Y	HCC2998	large intestine	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1111
p.R482H	SNU-1040	large intestine	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1389
p.R132W	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	129:136	Mutation altering degron motif	0.8634

Kaplan plot for SHQ1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHQ1

UniProt ID: Q6PI26

Entrez ID: 55164

Protein name: Protein SHQ1 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHQ1 in