DegronMD

Uniprot ID: Q6PI26

Source protein: Protein SHQ1 homolog

Source gene: SHQ1

Class: DEG_SCF_FBW7_2

Location: 129:136

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 83.45

COIL: 0.7691

CONS_SCORE: 0.334

DSS_SCORE: 0.5604

HELIX: 0.1664

FCONS_SCORE: 1.0599

RIG_SCORE: 0.8113

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R132W	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	0.8634
p.C134Y	SIDM00969	Ovarian Carcinoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	0.5976
p.C134Y	SIDM00087	Plasma Cell Myeloma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	0.5976
p.C134Y	SIDM00793	Burkitt's Lymphoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	0.5976
p.C134Y	SIDM00068	Colorectal Carcinoma	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	0.5976
p.C134Y	SIDM01525	Acute Myeloid Leukemia	GDSC	IEQTPCEE	DEG_SCF_FBW7_2	0.5976
p.L137M	DO228976	LICA	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	0.3056
p.W127C	TCGA-CV-A6K1	HNSC	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	0.2778
p.W127C	DO52078	HNSC	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	0.2778
p.S138L	TCGA-EB-A6QY	SKCM	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	0.2778
p.S138L	DO48702	SKCM	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	0.2778
p.D139G	DO41542	UCEC	ICGC	IEQTPCEE	DEG_SCF_FBW7_2	0.25
p.V140G	SW684	soft_tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	0.2222
p.G123E	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	0.1667
p.D122N	TCGA-A5-A0G1	UCEC	TCGA	IEQTPCEE	DEG_SCF_FBW7_2	0.1389
p.G121E	AN3-CA	endometrium	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	0.1111
p.H119Y	TGBC11TKB	stomach	COSMIC	IEQTPCEE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PI26	Protein SHQ1 homolog	DEG_SCF_FBW7_2	129:136	IEQTPCEE	FBXW7	0.9919	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons