DegronMD

Uniprot ID: Q6PI26

Source protein: Protein SHQ1 homolog

Source gene: SHQ1

Class: DEG_SCF_TRCP1_1

Location: 470:475

E3 ligase: BTRC

DEGRON score: 0.7439

ASA_SCORE: 91

COIL: 0.9038

CONS_SCORE: 0.2908

DSS_SCORE: 0.817

HELIX: 0.0865

FCONS_SCORE: 1.1395

RIG_SCORE: 0.499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D470H	TCGA-05-5425	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.7688
p.D474Y	TCGA-19-5956	GBM	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.6214
p.D474E	TCGA-38-4632	LUAD	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.5647
p.E469Q	TCGA-N5-A4RJ	UCS	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.3056
p.D482Y	DO7066	CLLE	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.1389
p.D470E	DO229025	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.6758
p.S461R	DO26429	LUSC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0833
p.E470K	DO48601	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.7022
p.P466L	DO38051	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P466L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P466L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.S462Y	HCC2998	large_intestine	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.1111
p.R482H	SNU-1040	large_intestine	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_SCF_TRCP1_1	479:484	DSGSDS	BTRC	0.987	More...
Q6PI26	Protein SHQ1 homolog	DEG_SCF_TRCP1_1	470:475	DSGSDS	BTRC	0.7439	More...
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	22:27	DSGSDS	BTRC	0.9469	More...
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	620:625	DSGSDS	BTRC	0.9983	More...
Q9UPA5	Protein bassoon	DEG_SCF_TRCP1_1	2638:2643	DSGSDS	BTRC	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons