DegronMD

Uniprot ID: Q9UPA5

Source protein: Protein bassoon

Source gene: BSN

Class: DEG_SCF_TRCP1_1

Location: 2638:2643

E3 ligase: BTRC

DEGRON score: 0.9935

ASA_SCORE: 87.4167

COIL: 0.9298

CONS_SCORE: 0.9956

DSS_SCORE: 0.685

HELIX: 0.0552

FCONS_SCORE: 1.0924

RIG_SCORE: 0.4914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2642N	TCGA-DR-A0ZM	CESC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.5821
p.D2642N	DO6254	CESC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.5821
p.R2635C	TCGA-G3-A25S	LIHC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.R2635C	DO23018	LIHC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.R2628C	DO233782	GACA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0556
p.R2632C	DO233888	GACA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.1667
p.R2635L	DO229015	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.25
p.R2628L	DO229037	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0556
p.P2634S	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P2634S	SIDM00170	Head and Neck Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P2634S	ACH-000196	Breast Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	0.2222
p.P2634S	ACH-000682	Head and Neck Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_SCF_TRCP1_1	479:484	DSGSDS	BTRC	0.987	More...
Q6PI26	Protein SHQ1 homolog	DEG_SCF_TRCP1_1	470:475	DSGSDS	BTRC	0.7439	More...
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	22:27	DSGSDS	BTRC	0.9469	More...
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	620:625	DSGSDS	BTRC	0.9983	More...
Q9UPA5	Protein bassoon	DEG_SCF_TRCP1_1	2638:2643	DSGSDS	BTRC	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons