DegronMD - Q8WXG6(MADD)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1153Q	TCGA-78-7154	LUAD	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.0833
p.A1211D	TCGA-A5-A0G2	UCEC	TCGA	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.A1211D	DO41235	UCEC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.T1208I	TCGA-AA-A010	COAD	TCGA	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.3056
p.L1209I	TCGA-BR-8487	STAD	TCGA	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2778
p.L1209I	DO47867	STAD	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2778
p.L1167M	TCGA-C8-A134	BRCA	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.5999
p.L1167M	DO1316	BRCA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.5999
p.M626V	TCGA-CN-6016	HNSC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.3056
p.M626V	DO14470	HNSC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.3056
p.S615F	TCGA-D3-A51G	SKCM	TCGA	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.1944
p.S615F	DO47700	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.1944
p.S1166N	TCGA-DD-A3A9	LIHC	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.5958
p.S1166N	DO44888	LIHC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.5958
p.L1215F	TCGA-IR-A3LK	CESC	TCGA	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1111
p.K1205N	DO4173	BRCA	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation altering degron motif	0.6918
p.E1165K	DO5207	BRCA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.7022
p.E1165K	DO14838	HNSC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.7022
p.L1154F	DO44299	CESC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.1111
p.G1208A	DO49066	HNSC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.3056
p.R611L	DO228474	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.0833
p.R611L	DO228806	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.0833
p.S1163I	DO228971	LICA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.7341
p.S634F	DO229054	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation rewiring degron network	0.0833
p.H1196R	DO26480	LUSC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1667
p.T1168S	DO221125	MALY	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.7116
p.R1212C	DO222638	MELA	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1944
p.K1194E	DO42408	UCEC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1111
p.G622A	SIDM02032	Pancreatic Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.754
p.A1161T	SIDM00255	Neuroblastoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.A1161T	SIDM00042	Pancreatic Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.A1161T	SIDM00885	Breast Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.A1161T	SIDM00869	Non-Cancerous	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.A1161T	SIDM00854	Burkitt's Lymphoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.A1161T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.3056
p.I1159M	SIDM00779	Colorectal Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.25
p.I1159M	NCI-H716	large intestine	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.25
p.D620G	SIDM01257	Hepatocellular Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.7198
p.D620G	SIDM00062	Hepatocellular Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.7198
p.D620G	ACH-000671	Liver Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.7198
p.D620G	ACH-002395	Liver Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.7198
p.D620G	HUH-6-clone5	liver	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	620:625	Mutation altering degron motif	0.7198
p.S1216N	ACH-002669	Colon/Colorectal Cancer	CCLE	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.0833
p.P1162L	MDST8	large intestine	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation altering degron motif	0.7582
p.P1205L	MDST8	large intestine	COSMIC	SNSSGE	DEG_Kelch_Keap1_1	1202:1207	Mutation altering degron motif	0.7582
p.R1171H	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	1162:1168	Mutation rewiring degron network	0.25

Kaplan plot for MADD in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MADD

UniProt ID: Q8WXG6

Entrez ID: 8567

Protein name: MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MADD in