DegronMD

Uniprot ID: Q8WXG6

Source protein: MAP kinase-activating death domain protein

Source gene: MADD

Class: DEG_SCF_TRCP1_1

Location: 1162:1168

E3 ligase: BTRC

DEGRON score: 0.9972

ASA_SCORE: 75.1286

COIL: 0.895

CONS_SCORE: 0.3278

DSS_SCORE: 0.552

HELIX: 0.0543

FCONS_SCORE: 1.0832

RIG_SCORE: 0.6621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1153Q	TCGA-78-7154	LUAD	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	0.0833
p.L1167M	TCGA-C8-A134	BRCA	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	0.5999
p.L1167M	DO1316	BRCA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.5999
p.S1166N	TCGA-DD-A3A9	LIHC	TCGA	DSGVSLT	DEG_SCF_TRCP1_1	0.5958
p.S1166N	DO44888	LIHC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.5958
p.E1165K	DO5207	BRCA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.7022
p.E1165K	DO14838	HNSC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.7022
p.L1154F	DO44299	CESC	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.1111
p.S1163I	DO228971	LICA	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.7341
p.T1168S	DO221125	MALY	ICGC	DSGVSLT	DEG_SCF_TRCP1_1	0.7116
p.A1161T	SIDM00255	Neuroblastoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.A1161T	SIDM00042	Pancreatic Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.A1161T	SIDM00885	Breast Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.A1161T	SIDM00869	Non-Cancerous	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.A1161T	SIDM00854	Burkitt's Lymphoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.A1161T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.3056
p.I1159M	SIDM00779	Colorectal Carcinoma	GDSC	DSGVSLT	DEG_SCF_TRCP1_1	0.25
p.I1159M	NCI-H716	large_intestine	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	0.25
p.P1162L	MDST8	large_intestine	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	0.7582
p.R1171H	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSLT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	1162:1168	DSGVSLT	BTRC	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons