DegronMD

Uniprot ID: Q8WXG6

Source protein: MAP kinase-activating death domain protein

Source gene: MADD

Class: DEG_Kelch_Keap1_1

Location: 1202:1207

E3 ligase: KEAP1

DEGRON score: 0.9921

ASA_SCORE: 79.0667

COIL: 0.8778

CONS_SCORE: 0.4051

DSS_SCORE: 0.5724

HELIX: 0.0492

FCONS_SCORE: 1.0404

RIG_SCORE: 0.6293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1211D	TCGA-A5-A0G2	UCEC	TCGA	SNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A1211D	DO41235	UCEC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.2222
p.T1208I	TCGA-AA-A010	COAD	TCGA	SNSSGE	DEG_Kelch_Keap1_1	0.3056
p.L1209I	TCGA-BR-8487	STAD	TCGA	SNSSGE	DEG_Kelch_Keap1_1	0.2778
p.L1209I	DO47867	STAD	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.2778
p.L1215F	TCGA-IR-A3LK	CESC	TCGA	SNSSGE	DEG_Kelch_Keap1_1	0.1111
p.K1205N	DO4173	BRCA	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.6918
p.G1208A	DO49066	HNSC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.3056
p.H1196R	DO26480	LUSC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.1667
p.R1212C	DO222638	MELA	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.1944
p.K1194E	DO42408	UCEC	ICGC	SNSSGE	DEG_Kelch_Keap1_1	0.1111
p.S1216N	ACH-002669	Colon/Colorectal Cancer	CCLE	SNSSGE	DEG_Kelch_Keap1_1	0.0833
p.P1205L	MDST8	large_intestine	COSMIC	SNSSGE	DEG_Kelch_Keap1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXG6	MAP kinase-activating death domain protein	DEG_Kelch_Keap1_1	1202:1207	SNSSGE	KEAP1	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons