DegronMD

Uniprot ID: Q8WXG6

Source protein: MAP kinase-activating death domain protein

Source gene: MADD

Class: DEG_SCF_TRCP1_1

Location: 620:625

E3 ligase: BTRC

DEGRON score: 0.9983

ASA_SCORE: 70.8833

COIL: 0.9152

CONS_SCORE: 0.514

DSS_SCORE: 0.7981

HELIX: 0.0593

FCONS_SCORE: 1.1152

RIG_SCORE: 0.5561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M626V	TCGA-CN-6016	HNSC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.3056
p.M626V	DO14470	HNSC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.3056
p.S615F	TCGA-D3-A51G	SKCM	TCGA	DSGSDS	DEG_SCF_TRCP1_1	0.1944
p.S615F	DO47700	SKCM	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.1944
p.R611L	DO228474	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0833
p.R611L	DO228806	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0833
p.S634F	DO229054	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	0.0833
p.G622A	SIDM02032	Pancreatic Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.754
p.D620G	SIDM01257	Hepatocellular Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.D620G	SIDM00062	Hepatocellular Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.D620G	ACH-000671	Liver Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.D620G	ACH-002395	Liver Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	0.7198
p.D620G	HUH-6-clone5	liver	COSMIC	DSGSDS	DEG_SCF_TRCP1_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30203	T-cell differentiation antigen CD6	DEG_SCF_TRCP1_1	479:484	DSGSDS	BTRC	0.987	More...
Q6PI26	Protein SHQ1 homolog	DEG_SCF_TRCP1_1	470:475	DSGSDS	BTRC	0.7439	More...
Q8WVC0	RNA polymerase-associated protein LEO1	DEG_SCF_TRCP1_1	22:27	DSGSDS	BTRC	0.9469	More...
Q8WXG6	MAP kinase-activating death domain protein	DEG_SCF_TRCP1_1	620:625	DSGSDS	BTRC	0.9983	More...
Q9UPA5	Protein bassoon	DEG_SCF_TRCP1_1	2638:2643	DSGSDS	BTRC	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons