DegronMD - Q9UPA5(BSN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q3191H	TCGA-37-3789	LUSC	TCGA	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.647
p.Q3191H	DO26743	LUSC	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.647
p.P1944S	TCGA-46-3768	LUSC	TCGA	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.1111
p.P1944S	DO26466	LUSC	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.1111
p.P1944S	DO229446	SKCA	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.1111
p.R78W	TCGA-A5-A0G2	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.R78W	DO41235	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.3056
p.E3190Q	TCGA-AC-A23H	BRCA	TCGA	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.6744
p.E3190Q	DO2401	BRCA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.6744
p.R3203C	TCGA-AR-A0TZ	BRCA	TCGA	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.1667
p.R3203C	DO2287	BRCA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.1667
p.R3203C	DO52389	LUSC	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.1667
p.E84K	TCGA-B0-5709	KIRC	TCGA	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.E84K	TCGA-CM-5864	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.E84K	DO8690	COAD	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.E84K	DO16607	KIRC	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.S992L	TCGA-BH-A0DD	BRCA	TCGA	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.3056
p.S992L	DO2008	BRCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.3056
p.A1318V	TCGA-D3-A8GM	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.1944
p.A1318V	DO50288	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.1944
p.P1310S	TCGA-DA-A3F8	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation altering degron motif	0.6752
p.P1310S	DO37418	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation altering degron motif	0.6752
p.D2642N	TCGA-DR-A0ZM	CESC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation altering degron motif	0.5821
p.D2642N	DO6254	CESC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation altering degron motif	0.5821
p.S2650P	TCGA-E6-A1LX	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	2649:2653	Mutation altering degron motif	0.5641
p.S2650P	DO41020	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	2649:2653	Mutation altering degron motif	0.5641
p.P3390S	TCGA-EE-A181	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	3392:3396	Mutation rewiring degron network	0.2778
p.P3390S	DO37444	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	3392:3396	Mutation rewiring degron network	0.2778
p.T1312I	TCGA-EE-A20H	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation altering degron motif	0.5966
p.T1312I	DO37986	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation altering degron motif	0.5966
p.P996S	TCGA-EL-A4K4	THCA	TCGA	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1944
p.P996S	DO39546	THCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1944
p.Y1942C	TCGA-EY-A549	UCEC	TCGA	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.0556
p.Y1942C	DO48174	UCEC	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.0556
p.R2635C	TCGA-G3-A25S	LIHC	TCGA	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.25
p.R2635C	DO23018	LIHC	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.25
p.P1949S	TCGA-GF-A4EO	SKCM	TCGA	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.25
p.P1949S	DO47559	SKCM	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.25
p.P1175S	TCGA-GM-A2D9	BRCA	TCGA	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.2222
p.P1175S	DO4810	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.2222
p.S1177F	TCGA-GM-A2D9	BRCA	TCGA	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.1667
p.S1177F	DO4810	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.1667
p.S1177F	ACH-002396	Bone Cancer	CCLE	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.1667
p.S1177F	Sarc9371	bone	COSMIC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.1667
p.S992W	TCGA-MN-A4N5	LUAD	TCGA	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.3056
p.S992W	DO45332	LUAD	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.3056
p.G1170S	DO48395	BLCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation altering degron motif	0.5882
p.G1170S	DO229344	BTCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation altering degron motif	0.5882
p.G74R	DO224704	BRCA	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation altering degron motif	0.6457
p.E1166K	DO228509	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation altering degron motif	0.591
p.R1956W	DO229339	BTCA	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.3056
p.G1959E	DO52722	CLLE	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.2222
p.V3197M	DO8730	COAD	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.6097
p.T1954I	DO222853	COCA	ICGC	PPTY	ITCH	1952:1955	Mutation altering degron motif	0.5966
p.S3396I	DO48242	ESCA	ICGC	AVSSS	DEG_SPOP_SBC_1	3392:3396	Mutation altering degron motif	0.7341
p.A2655S	DO233102	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	2649:2653	Mutation rewiring degron network	0.2778
p.M1159V	DO233088	GACA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.1944
p.E84G	DO233202	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1389
p.R2628C	DO233782	GACA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.0556
p.R2632C	DO233888	GACA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.1667
p.P1307S	DO233935	GACA	ICGC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation altering degron motif	0.6752
p.R974L	DO228948	LICA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.0556
p.R2635L	DO229015	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.25
p.G3182V	DO229029	LICA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.2222
p.G1170V	DO229028	LICA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation altering degron motif	0.6421
p.R2628L	DO229037	LICA	ICGC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.0556
p.G3188S	DO229055	LICA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation altering degron motif	0.5882
p.L1161F	DO222494	MELA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	1164:1171	Mutation rewiring degron network	0.25
p.P1947S	DO222662	MELA	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.1944
p.G3201D	DO222843	MELA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.2222
p.P1944L	DO229446	SKCA	ICGC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.1111
p.R976H	DO229257	THCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1111
p.R976H	DO41056	UCEC	ICGC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1111
p.T76N	DO229211	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation altering degron motif	0.8166
p.P2634S	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.2222
p.P2634S	SIDM00170	Head and Neck Carcinoma	GDSC	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.2222
p.P2634S	ACH-000196	Breast Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.2222
p.P2634S	ACH-000682	Head and Neck Cancer	CCLE	DSGSDS	DEG_SCF_TRCP1_1	2638:2643	Mutation rewiring degron network	0.2222
p.L80P	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.25
p.L80P	ACH-000697	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.25
p.L80P	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.25
p.S3179G	SIDM00683	Prostate Carcinoma	GDSC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.1389
p.S3179G	LNCaP-Clone-FGC	prostate	COSMIC	SSGYEQGKVPEV	DEG_COP1_1	3186:3197	Mutation rewiring degron network	0.1389
p.P1314H	SIDM00422	Hodgkin's Lymphoma	GDSC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.3056
p.P1314H	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.3056
p.S1322P	SIDM00217	Colorectal Carcinoma	GDSC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.0833
p.S1322P	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.0833
p.S1322P	SNU-1040	large intestine	COSMIC	PLTPGTS	DEG_SCF_FBW7_1	1307:1313	Mutation rewiring degron network	0.0833
p.Q1958H	SIDM01608	Endometrial Carcinoma	GDSC	PPTY	ITCH	1952:1955	Mutation rewiring degron network	0.25
p.S998Y	SIDM01612	Endometrial Carcinoma	GDSC	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1389
p.S998Y	ACH-000946	Endometrial/Uterine Cancer	CCLE	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1389
p.P85L	ACH-000025	Brain Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	73:77	Mutation rewiring degron network	0.1111
p.P996H	ACH-001367	Neuroblastoma	CCLE	PASTPSYT	DEG_SCF_FBW7_1	984:991	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BSN

UniProt ID: Q9UPA5

Entrez ID: 8927

Protein name: Protein bassoon (Zinc finger protein 231)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BSN in