DegronMD

Uniprot ID: Q9UPA5

Source protein: Protein bassoon

Source gene: BSN

Class: DEG_SCF_FBW7_1

Location: 1164:1171

E3 ligase: FBXW7

DEGRON score: 0.9557

ASA_SCORE: 91.6625

COIL: 0.9681

CONS_SCORE: 0.9837

DSS_SCORE: 0.646

HELIX: 0.0134

FCONS_SCORE: 1.0265

RIG_SCORE: 0.5685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1175S	TCGA-GM-A2D9	BRCA	TCGA	PTETPSGS	DEG_SCF_FBW7_1	0.2222
p.P1175S	DO4810	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.2222
p.S1177F	TCGA-GM-A2D9	BRCA	TCGA	PTETPSGS	DEG_SCF_FBW7_1	0.1667
p.S1177F	DO4810	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.1667
p.S1177F	ACH-002396	Bone Cancer	CCLE	PTETPSGS	DEG_SCF_FBW7_1	0.1667
p.S1177F	Sarc9371	bone	COSMIC	PTETPSGS	DEG_SCF_FBW7_1	0.1667
p.G1170S	DO48395	BLCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.5882
p.G1170S	DO229344	BTCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.5882
p.E1166K	DO228509	BRCA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.591
p.M1159V	DO233088	GACA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.1944
p.G1170V	DO229028	LICA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.6421
p.L1161F	DO222494	MELA	ICGC	PTETPSGS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPA5	Protein bassoon	DEG_SCF_FBW7_1	1164:1171	PTETPSGS	FBXW7	0.9557	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons